Trional (Methylsulfonal) is a

sedative-hypnotic A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are central nervous system (CNS) depressants and interact with brain activity, causing its deceleration. Various kinds of sedatives ca ...

and

anesthetic An anesthetic (American English) or anaesthetic (British English; see spelling differences) is a drug used to induce anesthesia ⁠— ⁠in other words, to result in a temporary loss of sensation or awareness. They may be divided into t ...

drug A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via insufflation (medicine), inhalation, drug i ...

with

GABAergic In molecular biology and physiology, something is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter gamma-aminobutyric acid (GABA). For example, a synapse is GABAergic if it uses GABA as its neurotransmitter, and a GABAergic ...

action Action may refer to: * Action (philosophy), something which is done by a person * Action principles the heart of fundamental physics * Action (narrative), a literary mode * Action fiction, a type of genre fiction * Action game, a genre of video gam ...

s. It has similar effects to

sulfonal Sulfonmethane (sulfonomethane, sulfonal, acetone diethyl sulfone) is a chemical compound first synthesized by Eugen Baumann in 1888 and introduced as a hypnotic drug by Alfred Kast later on, but now superseded by newer and safer sedatives. Its ap ...

, except it is faster acting.

History

Trional was prepared and introduced by

Eugen Baumann Eugen Baumann (12 December 1846 – 3 November 1896) was a German chemist. He was one of the first people to create polyvinyl chloride (PVC), and, together with Carl Schotten, he discovered the Schotten-Baumann reaction. Life Baumann was born i ...

and

Alfred Kast Alfred Kast (25 July 1856 in Illenau, near Achern – 7 January 1903) was a German internist. He studied medicine at the Universities of Heidelberg, Freiburg and Leipzig, earning his doctorate in 1879. He served as an assistant to Wilhelm Heinric ...

in 1888.

Cultural references

Appeared in Agatha Christie's ''

Murder on the Orient Express ''Murder on the Orient Express'' is a work of detective fiction by English writer Agatha Christie featuring the Belgian detective Hercule Poirot. It was first published in the United Kingdom by the Collins Crime Club on 1 January 1934. In the U ...

'', ''

And Then There Were None ''And Then There Were None'' is a mystery fiction, mystery novel by the English writer Agatha Christie, who described it as the most difficult of her books to write. It was first published in the United Kingdom by the Collins Crime Club on 6 N ...

'', and other novels such as John Bude's '' The Lake District Murder'' as a sleep-inducing sedative; and in ''

In Search of Lost Time ''In Search of Lost Time'' (), first translated into English as ''Remembrance of Things Past'', and sometimes referred to in French as ''La Recherche'' (''The Search''), is a novel in seven volumes by French author Marcel Proust. This early twen ...

'' (Sodom and Gomorrah) by

Marcel Proust Valentin Louis Georges Eugène Marcel Proust ( ; ; 10 July 1871 – 18 November 1922) was a French novelist, literary critic, and essayist who wrote the novel (in French – translated in English as ''Remembrance of Things Past'' and more r ...

as a

hypnotic A hypnotic (from Ancient Greek, Greek ''Hypnos'', sleep), also known as a somnifacient or soporific, and commonly known as sleeping pills, are a class of psychoactive drugs whose primary function is to sleep induction, induce sleep and to trea ...

Sax Rohmer Arthur Henry "Sarsfield" Ward (15 February 1883 – 1 June 1959), better known as Sax Rohmer, was an English novelist. He is best remembered for his series of novels featuring the master criminal Fu Manchu."Rohmer, Sax" by Jack Adrian in David ...

also references trional in his novel ''

Dope Dope may refer to: Chemistry Biochemistry * Dope, a slang word for a euphoria-producing drug, particularly: ** Cocaine ** Cannabis (drug) ** Heroin ** Opioid * DOPE, or 1,2-Dioleoyl-''sn''-glycero-3-phosphoethanolamine, a phospholipid * Discret ...

''.

References

Hypnotics GABAA receptor positive allosteric modulators Sulfones {{sedative-stub

History

Cultural references

See also

References