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Sudha Bhattacharya (born 7 March 1952) is an Indian academic, scientist and a writer. She is recognized primarily for her in-depth study of
Entamoeba histolytica ''Entamoeba histolytica'' is an anaerobic organism, anaerobic parasitic amoebozoan, part of the genus ''Entamoeba''. Predominantly infecting humans and other primates causing amoebiasis, ''E. histolytica'' is estimated to infect about 35-50 mil ...
, a parasitic protozoan that causes
amoebiasis Amoebiasis, or amoebic dysentery, is an infection of the intestines caused by a parasitic amoeba '' Entamoeba histolytica''. Amoebiasis can be present with no, mild, or severe symptoms. Symptoms may include lethargy, loss of weight, colon ...
: Dr. Bhattacharya's laboratory first detected
Ribosomal RNA Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein synthesis in ribosomes. Ribosomal RNA is transcribed from ribosomal ...
genes on Circular DNA, while studying the parasite, and also discovered families of
retrotransposons Retrotransposons (also called Class I transposable elements) are transposable element, mobile elements which move in the host genome by converting their transcribed RNA into DNA through reverse transcription. Thus, they differ from Class II trans ...
in the parasite
genome A genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as ...
. Her work has primarily been in the fields of Molecular Parasitology and
Gene Regulation Regulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are wide ...
. Bhattacharya is a professor at the School of Environmental Sciences,
Jawaharlal Nehru University Jawaharlal Nehru University (JNU; ISO: Javāharalāla Neharū Viśvavidyālaya) is a public research university located in Delhi, India. It was established in 1969 and named after Jawaharlal Nehru, India's first Prime Minister. The university ...
(JNU). She is a fellow at
The National Academy of Sciences, India The National Academy of Sciences, India, also known as NASI, was established in 1930 and is the oldest science academy of India. It is located in Prayagraj, Uttar Pradesh. Prof. Meghnad Saha was the founder president. Fellows *Suddhasatwa Basu ...
,
Indian Academy of Sciences The Indian Academy of Sciences, Bangalore was founded by Indian Physicist and List of Nobel laureates, Nobel Laureate Chandrasekhara Venkata Raman, C. V. Raman, and was registered as a society on 27 April 1934. Inaugurated on 31 July 1934, it ...
and
Indian National Science Academy The Indian National Science Academy (INSA) is a national academy in New Delhi New Delhi (; ) is the Capital city, capital of India and a part of the Delhi, National Capital Territory of Delhi (NCT). New Delhi is the seat of all three b ...
(2014).


Education and career

Sudha Bhattacharya attended
University of Delhi The Delhi University (DU, ISO 15919, ISO: ), also and officially known as the University of Delhi, is a collegiate university, collegiate research university, research Central university (India), central university located in Delhi, India. It ...
where she graduated with a BSc.(Hons) degree in Botany in the year 1971 and then proceeded to the
Indian Agricultural Research Institute The Indian Agricultural Research Institute (IARI), commonly known as the Pusa Institute, is India's national institute for agricultural research, education and extension. The name Pusa Institute is derived from the fact that the institute was ...
,
New Delhi New Delhi (; ) is the Capital city, capital of India and a part of the Delhi, National Capital Territory of Delhi (NCT). New Delhi is the seat of all three branches of the Government of India, hosting the Rashtrapati Bhavan, New Parliament ...
where she obtained her MSc. in Biochemistry and Molecular Biology. She completed her post-graduation in 1973 and then, in 1977, earned a Ph. D. for research on regulation of
RNA synthesis Transcription is the process of copying a segment of DNA into RNA for the purpose of gene expression. Some segments of DNA are transcribed into RNA molecules that can encode proteins, called messenger RNA (mRNA). Other segments of DNA are transc ...
in
Escherichia coli ''Escherichia coli'' ( )Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. is a gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus '' Escherichia'' that is commonly fo ...
. She has conducted post-doctoral research on
bacteriophage A bacteriophage (), also known informally as a phage (), is a virus that infects and replicates within bacteria. The term is derived . Bacteriophages are composed of proteins that Capsid, encapsulate a DNA or RNA genome, and may have structu ...
genetics at
Stanford University Leland Stanford Junior University, commonly referred to as Stanford University, is a Private university, private research university in Stanford, California, United States. It was founded in 1885 by railroad magnate Leland Stanford (the eighth ...
(1977–79), bacterial DNA replication at the
Boston Biomedical Research Institute Boston Biomedical Research Institute (BBRI) was a non-profit institution concentrating on basic biomedical research to promote the understanding of human diseases (including heart disease, cancer, muscular dystrophy and Alzheimer's Alzheim ...
(1979-1981) and studied axenic cultivation at the
National Institutes of Health The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...
(1985–86). Prior to joining the
Jawaharlal Nehru University Jawaharlal Nehru University (JNU; ISO: Javāharalāla Neharū Viśvavidyālaya) is a public research university located in Delhi, India. It was established in 1969 and named after Jawaharlal Nehru, India's first Prime Minister. The university ...
, Bhattacharya has worked at the
All India Institute of Medical Sciences The All India Institutes of Medical Sciences (AIIMS) is a group of autonomous government public medical universities of higher education under the jurisdiction of Ministry of Health and Family Welfare, Government of India. These institutes ha ...
as a research officer from 1981–82 and at the
Tata Research Development and Design Centre Tata Research Development and Design Centre (TRDDC) is a software research centre in Pune, India, established by Tata Group's TCS in 1981. TRDDC undertakes research in Machine Learning, Software Engineering, Process Engineering and Systems R ...
as a
scientist A scientist is a person who Scientific method, researches to advance knowledge in an Branches of science, area of the natural sciences. In classical antiquity, there was no real ancient analog of a modern scientist. Instead, philosophers engag ...
from 1982-85 to research on DNA-based diagnostic methods for common diseases. She joined JNU in 1986 as an
Assistant Professor Assistant professor is an academic rank just below the rank of an associate professor used in universities or colleges, mainly in the United States, Canada, Japan, and South Korea. Overview This position is generally taken after earning a doct ...
and set up her lab to study '' E. histolytica.'' She has also served on the academic committee of various boards affiliated to JNU. In her attempt towards recognising environmentalists who rely on traditional knowledge, she found Jadhav Payeng from
Assam Assam (, , ) is a state in Northeast India, northeastern India, south of the eastern Himalayas along the Brahmaputra Valley, Brahmaputra and Barak River valleys. Assam covers an area of . It is the second largest state in Northeast India, nor ...
who converted 1,00 acres of dense land into a forest for rhinos and elephants.


Academic and Research Achievements

Dr. Bhattacharya received global acclaim for her novel findings in the field of simple
molecular biology Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactio ...
of E. Histolytica. Her lab found the existence of
ribosomal RNA Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein synthesis in ribosomes. Ribosomal RNA is transcribed from ribosomal ...
genes on round
DNA Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...
, and located families of
retrotransposon Retrotransposons (also called Class I transposable elements) are mobile elements which move in the host genome by converting their transcribed RNA into DNA through reverse transcription. Thus, they differ from Class II transposable elements, or ...
s inside the parasite genome. Study on the replication of rDNA established the existence of replication origins inside the rDNA circle, which were differentially used in response to growth strain.  Expression evaluation of rRNA and r-proteins discovered the post-transcriptional regulation of ribosomal
biogenesis Spontaneous generation is a Superseded scientific theories, superseded scientific theory that held that living creatures could arise from abiotic component, non-living matter and that such processes were commonplace and regular. It was Hypoth ...
. Her work on
retrotransposon Retrotransposons (also called Class I transposable elements) are mobile elements which move in the host genome by converting their transcribed RNA into DNA through reverse transcription. Thus, they differ from Class II transposable elements, or ...
s confirmed that retrotransposition is observed by means of excessive frequency recombination- which could contribute to series polymorphism determined in retrotransposons. Her lab also applied the widespread insertion site polymorphism of retrotransposons to broaden a way for pressure typing of E. Histolytica clinical isolates.


Awards and honours

* Robert McNamara Fellowship,
World Bank The World Bank is an international financial institution that provides loans and Grant (money), grants to the governments of Least developed countries, low- and Developing country, middle-income countries for the purposes of economic development ...
(1985) * Rockefeller Biotechnology Career Development Award (1987) * Fogarty International Research Collaboration Award (1996 and 2001) * Fellow of
Indian Academy of Sciences The Indian Academy of Sciences, Bangalore was founded by Indian Physicist and List of Nobel laureates, Nobel Laureate Chandrasekhara Venkata Raman, C. V. Raman, and was registered as a society on 27 April 1934. Inaugurated on 31 July 1934, it ...
(2001),
National Academy of Sciences, India The National Academy of Sciences, India, also known as NASI, was established in 1930 and is the oldest science academy of India. It is located in Prayagraj, Uttar Pradesh. Prof. Meghnad Saha was the founder president. Fellows * Suddhasatwa Bas ...
(2008) and
Indian National Science Academy The Indian National Science Academy (INSA) is a national academy in New Delhi New Delhi (; ) is the Capital city, capital of India and a part of the Delhi, National Capital Territory of Delhi (NCT). New Delhi is the seat of all three b ...
(2014)
J.C. Bose National Fellow
(2015) *Member of the Guha Research Conference (1993)


Other contributions

Dr. Bhattacharya has served in the Academic Committees of various JNU-affiliated Institutes such as CDRI, ICGEB to name few. She served as Dean, School of Environmental Sciences (2010–12) and played a major role in the all-round improvement of the academic programme. She has been a sectional committee member of the Animal and Plant Science committee of Indian Academy of Sciences, Bangalore and is currently nominated to its Council. She is member Sectional Committee X of INSA; member Research committee, Animal Sciences & Biotechnology, CSIR; member, Animal Science Program Advisory Committee, SERB; member Governing body of SN Bose National Center of Basic Science, Kolkata; member Scientific Advisory committee, Institute of Pathology, New Delhi; member Editorial Board of J. Bioscience.


See also

* Alok Bhattacharya


References

{{DEFAULTSORT:Bhattacharya, Sudha Living people 1952 births Articles created or expanded during Women's History Month (India) - 2014 Indian women biologists Fellows of the Indian National Science Academy Fellows of the Indian Academy of Sciences Fellows of the National Academy of Sciences, India 20th-century Indian biologists 20th-century Indian women scientists