Steven A. Rosenberg (born 2 August 1940) is an American cancer researcher and surgeon, chief of Surgery at the

National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. T ...

Bethesda, Maryland Bethesda () is an unincorporated, census-designated place in southern Montgomery County, Maryland. It is located just northwest of Washington, D.C. It takes its name from a local church, the Bethesda Meeting House (1820, rebuilt 1849), which ...

and a

Professor Professor (commonly abbreviated as Prof.) is an academic rank at universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who professes". Professor ...

of Surgery at the

Uniformed Services University of Health Sciences Uniformed Services University of the Health Sciences (USU) is a Outline of health sciences, health science university of the Federal government of the United States, U.S. federal government. The primary mission of the school is to prepare graduate ...

and the George Washington University School of Medicine and Health Sciences. He pioneered the development of

immunotherapy Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system. Immunotherapies designed to elicit or amplify an immune response are classified as ''activation immunotherapies,'' while immunotherap ...

that has resulted in the first effective immunotherapies and the development of

gene therapy Gene therapy is a medical field which focuses on the genetic modification of cells to produce a therapeutic effect or the treatment of disease by repairing or reconstructing defective genetic material. The first attempt at modifying human D ...

. He is the first researcher to successfully insert foreign genes into humans.

Early life

Rosenberg was born in 1940, in the

Bronx The Bronx () is a borough of New York City, coextensive with Bronx County, in the state of New York. It is south of Westchester County; north and east of the New York City borough of Manhattan, across the Harlem River; and north of the New ...

, the youngest of three children of Jewish immigrants from

Poland Poland, officially the Republic of Poland, , is a country in Central Europe. Poland is divided into Voivodeships of Poland, sixteen voivodeships and is the fifth most populous member state of the European Union (EU), with over 38 mill ...

, who owned a

luncheonette A lunch counter (also known as a luncheonette) is, in the US, a small restaurant, similar to a diner, where the patron sits on a stool on one side of the counter and the server or person preparing the food serves from the opposite side of the c ...

. He met his wife to be, Alice O’Connell during his residency at Boston’s

Peter Bent Brigham Hospital Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two fo ...

, who was the chief nurse at the time. They got married in 1968 and have three daughters.

Methodology

He is accredited with developing the use of

IL-2 The Ilyushin Il-2 (Russian: Илью́шин Ил-2) is a ground-attack plane that was produced by the Soviet Union in large numbers during the Second World War. The word ''shturmovík'' (Cyrillic: штурмовик), the generic Russian term ...

and immune cells for the treatment of patients with melanoma in a procedure termed adoptive cell transfer. He has shown that expanding immune cells (known as tumor infiltrating lymphocytes) in the lab can be used to treat patients with melanoma and has published two important studies describing their use. The first in 2002, demonstrated that some patients with advanced melanoma can be treated to complete remission with a combination of

chemotherapy Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemothe ...

, immune cells and high doses of IL-2. The second, in 2006, demonstrated that the receptor of

T cells A T cell is a type of lymphocyte. T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell ...

can be transferred to immune cells and in combination with chemotherapy and high doses of IL-2 can be used to treat patients with melanoma. Although, this was the first time that the T cell receptor was used for gene therapy, it was not the first time that gene therapy was used in cancer. Tumor cells modified with a gene for immune growth factors such as

GM-CSF Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that ...

, had been used many years previously and continue to be used, although the efficacy of GM-CSF modified tumor lines as a cancer vaccine remain extremely modest, at best. There has been some debate as to the role of the T cells in treating the cancer in these studies as high-dose IL-2 and chemotherapy have also been shown to have anti-cancer properties. Nevertheless, the combination of chemotherapy, T cells and high-dose IL-2 was shown to be effective even in patients who had previously failed high-dose IL-2 treatment. Rosenberg has pioneered the use of adoptive

Education

Rosenberg graduated from the Bronx High School of Science. He received his B.A. (

biology Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditar ...

, 1961) and

M.D. Doctor of Medicine (abbreviated M.D., from the Latin ''Medicinae Doctor'') is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the M.D. denotes a professional degree. T ...

(1964) degrees from

Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hemisphere. It consiste ...

. He served a surgical internship and residency at the

, completing it in 1974. During his residency he also earned a Ph.D. in

biophysics Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. ...

from

Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of high ...

with

thesis A thesis ( : theses), or dissertation (abbreviated diss.), is a document submitted in support of candidature for an academic degree or professional qualification presenting the author's research and findings.International Standard ISO 7144 ...

titled ''The proteins of human

erythrocyte Red blood cells (RBCs), also referred to as red cells, red blood corpuscles (in humans or other animals not having nucleus in red blood cells), haematids, erythroid cells or erythrocytes (from Greek ''erythros'' for "red" and ''kytos'' for "holl ...

membrane A membrane is a selective barrier; it allows some things to pass through but stops others. Such things may be molecules, ions, or other small particles. Membranes can be generally classified into synthetic membranes and biological membranes. ...

s'' (in 1968/1969). Following the completion of his surgical residency, he became the Chief of Surgery at the

, a position he continues to hold. His research has focused on the immunotherapy of cancer.

Awards and honors

* 1992 Golden Plate Award of the

American Academy of Achievement The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet o ...

* 2011 William B. Coley Award for Distinguished Research in Tumor Immunology of the Cancer Research Institute * 2013

Keio Medical Science Prize The Keio Medical Science Prize ( Japanese: 慶應医学賞) is a Japanese prize in medical sciences. Introduction The prize is awarded to scientists who made significant contributions to the field of medical sciences or life sciences. And these c ...

* 2015 Medal of Honor of the

American Cancer Society The American Cancer Society (ACS) is a nationwide voluntary health organization dedicated to eliminating cancer. Established in 1913, the society is organized into six geographical regions of both medical and lay volunteers operating in more tha ...

* 2018 Albany Medical Center Prize in Medicine and Biomedical Research * 2019 Edogawa NICHE Prize * 2019

Szent-Györgyi Prize for Progress in Cancer Research The Szent-Györgyi Prize for Progress in Cancer Research, established by National Foundation for Cancer Research (NFCR) and named in honor of Albert Szent-Györgyi, Nobel Laureate and co-founder of NFCR, has been awarded annually since 2006 to out ...

* 2021

Dan David Prize The Dan David Prize is a major international award that recognizes and supports outstanding contributions to the study of history and other disciplines that shed light on the human past. It awards nine prizes of $300,000 each year to outstanding ...

Dan David Prize 2021
/ref>

References

External links

Gene therapy rids men of cancer
''

BBC News BBC News is an operational business division of the British Broadcasting Corporation (BBC) responsible for the gathering and broadcasting of news and current affairs in the UK and around the world. The department is the world's largest broad ...

'' (2006 coverage of cancer breakthrough discovered by his team)
"Cancer Miracles"
Robert Langreth, ''

Forbes ''Forbes'' () is an American business magazine owned by Integrated Whale Media Investments and the Forbes family. Published eight times a year, it features articles on finance, industry, investing, and marketing topics. ''Forbes'' also r ...