Steven R. Tannenbaum was born and grew up in the Rockaways of Queens,

New York City New York, often called New York City or NYC, is the most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the most densely populated major city in the U ...

. He attended the Hebrew Institute of Long Island through 9th grade, then moved to Hewlett, Long Island where he graduated from Woodmere H.S. in 1954. He attended the

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a Private university, private Land-grant university, land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern t ...

from 1954-1962, earning a B.S. in Food Technology in 1958 and a PhD. in Food Science in 1962. He was then appointed to Assistant Professor in 1964 in the Department of Food Science and Technology leading up to Full Professor in 1974. Throughout his career he was mentored by Samuel A. Goldblith up until his death in 2001. In 1973 Tannenbaum did a sabbatical at the Hebrew University of Jerusalem, where he decided to switch his career into cancer research at the suggestion of Gerald Wogan. He has held appointments at MIT including Director of the Division of Toxicology (1996-1998) which he cofounded along with Douglas Lauffenburger, of the Division, and then Department of Biological Engineering, the first new academic Department in the MIT School of Engineering in over a generation, and Co-Director from 1998 to July 2003. In 2003-2004 he was the Director of Research of the Cambridge University-MIT Institute.

Research interests

Tannenbaum’s areas of research include mechanisms of biochemical activation of chemicals to electrophilic forms that bind to DNA and proteins; application of biomarkers to the prediction of the severity of inflammatory disease; the role of endogenous nitric oxide in inflammation, cytotoxicity, and DNA damage; and development of new tools for drug metabolism, pharmacokinetics, and toxicology. Current research focuses on the causes of IBD, prognostic biomarkers for Dengue fever, human microphysiological systems for drug safety and PK/PD, and the role of nitric oxide in brain pathology, including Alzheimer’s Disease and ASD.

Notable contributions

The Tannenbaum laboratory has made important contributions to the etiology of cancer from both environmental and endogenous factors. Most important was the first discovery of the mammalian synthesis of nitrogen oxides, and its linkage to inflammation and injury. This led to a collaboration with Michael Marletta, whose discovery of the enzymatic source of nitric oxide revealed the source of one of the most important signaling molecules in biology. Other notable discoveries include biomarkers of exposure to chemical carcinogens, and predictive biomarkers of Dengue Hemorrhagic Fever. His laboratory also collaborated with Linda Griffith in the development of the LiverChip, a microphysiological, immunocompetent, flow-through human liver bioreactor.

Honors and awards

Dr. Tannenbaum has won a number of awards including being an Elected Member of the

National Academy of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, En ...

in 1996, Chemistry in Cancer Award of the

American Association for Cancer Research The American Association for Cancer Research (AACR) is the world's oldest and largest professional association related to cancer research. Based in Philadelphia, the AACR focuses on all aspects of cancer research, including basic, clinical, and tr ...

in 2008, Fellow of the

American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all ...

in 2011, and Fellow of the

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsi ...

in 2006. Other notable awards include

Samuel Cate Prescott Award The Samuel Cate Prescott Award has been awarded since 1964 by the Institute of Food Technologists (IFT) in Chicago, Illinois. It is awarded to food science or technology researchers who are under 36 years of age or who earned their highest degr ...

for Research, Institute of Food Technologists, 1970; Founders Award, ACS Division of Chemical Toxicology, 2013; Lifetime Achievement Award, NIH/NCI Cancer Redox Biology Faculty, 2012; Princess Takamatsu Distinguished Lecturer, Japan, 2006; Babcock Hart Award, Institute of Food Technologists, 1980.

References

External links

Tannenbaum's Publications

From Explosives to the Gas That Heals

Tannenbaum's Home Page
{{DEFAULTSORT:Tannenbaum, Steven George W. Hewlett High School alumni People from Hewlett, New York Massachusetts Institute of Technology alumni American food scientists Scientists from New York (state) People from Far Rockaway, Queens Members of the National Academy of Medicine