Steven J. Burakoff is a

cancer Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Po ...

specialist and the author of both ''Therapeutic Immunology'' (2001) and ''Graft-Vs.-Host Disease: Immunology, Pathophysiology, and Treatment'' (1990). He served as Director of The Tisch Cancer Institute at Mount Sinai (2007-2017), which was created in 2007 to focus on translational medicine. He is the Lillian and Henry M. Stratton Professor of Cancer Medicine at Mount Sinai Medical Center as well as Dean for Cancer Innovation and Chief, Pediatric Oncology at the Icahn School of Medicine.

Biography

Before joining Mount Sinai, he was recruited by

New York University School of Medicine The New York University Grossman School of Medicine is a medical school of New York University, a private research university in New York City. It was founded in 1841 and is one of two medical schools of the university, the other being the NYU G ...

to revitalize the research and treatment mission of NYU's Cancer Institute, which during his tenure experienced a 31 percent growth and a 50 percent increase in funding from the

National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...

. He completed a residency in medicine at New York Hospital-

Cornell Medical Center Weill Cornell Medicine (; officially Joan and Sanford I. Weill Medical College of Cornell University), originally Cornell University Medical College, is the medical school of Cornell University, located on the Upper East Side of Manhattan in Ne ...

and pursued fellowships in

immunology Immunology is a branch of biology and medicine that covers the study of Immune system, immune systems in all Organism, organisms. Immunology charts, measures, and contextualizes the Physiology, physiological functioning of the immune system in ...

at both

Rockefeller University The Rockefeller University is a Private university, private Medical research, biomedical Research university, research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and pro ...

and

Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...

. He has received 84 grants as of 2020 in fields related to core administration,

T-Cell T cells (also known as T lymphocytes) are an important part of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their ce ...

activation and regulation, as well as various immunological studies. His brother, Robert Burakoff, is a gastroenterologist at

Brigham and Women's Hospital Brigham and Women's Hospital (BWH or The Brigham) is a teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two ...

in Boston, MA.

Awards

*1995 Harvard Medical School Excellence in Mentoring Award *2006 Lynne Cohen Foundation Award * 2009 American Association of Immunologists Lifetime Achievement Award *2019 Elected a Distinguished Fellow of

American Association of Immunologists American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, p ...

Appointments and positions

* Director of The Tisch Cancer Institute at Mount Sinai * Past Director, Skirball Institute of Biomolecular Medicine,

* Board of Directors, Pharmacopeia Drug Discovery, Inc. *Board of Directors, Damon Runyon Cancer Research Foundation

Publications

Burakoff has published 404 articles as of 2020 and has been cited more than 23,000 times according to RearchGate.

Books

* Strom TB, Austen KF, Burakoff SJ. ''Therapeutic Immunology.'' Wiley-Blackwell, 2001 * Ferrara JLM, Deeg HJ, Burakoff SJ. ''Graft-Vs.-Host Disease: Immunology, Pathophysiology, and Treatment.'' Marcel Dekker, 1990

Other publications (partial list)

*''Interleukin-3 (IL-3)-induced c-fos activation is modulated by Gab2-calcineurin interaction.'' Pyarajan S, Matejovic G, Pratt JC, Baksh S, Burakoff SJ. Journal of Biological Chemistry. 2008 *''Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation.'' Jin YJ, Cai CY, Zhang X, Burakoff SJ. Journal of Immunology 2008 *''Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway.'' Sawasdikosol S, Pyarajan S, Alzabin S, Matejovic G, Burakoff SJ. Journal of Biological Chemistry, 2007 *''From bytes to bedside: data integration and

computational biology Computational biology refers to the use of techniques in computer science, data analysis, mathematical modeling and Computer simulation, computational simulations to understand biological systems and relationships. An intersection of computer sci ...

for translational cancer research.'' Mathew JP, Taylor BS, Bader GD, Pyarajan S, Antoniotti M, Chinnaiyan AM, Sander C, Burakoff SJ, Mishra B. PLoS Computational Biology, 2007 *''A CD8/Lck transgene is able to drive thymocyte differentiation.'' Fragoso RC, Pyarajan S, Irie HY, Burakoff SJ. Journal of Immunology, 2006 *''HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent.'' Jin YJ, Cai CY, Zhang X, Zhang HT, Hirst JA, Burakoff SJ. Journal of Immunology, 2005 *''CD4 phosphorylation partially reverses Nef down-regulation of CD4.'' Jin YJ, Zhang X, Boursiquot JG, Burakoff SJ. Journal of Immunology, 2004 *''Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells.'' Frazer-Abel AA, Baksh S, Fosmire SP, Willis D, Pierce AM, Meylemans H, Linthicum DS, Burakoff SJ, Coons T, Bellgrau D, Modiano JF. Journal of Pharmacology and Experimental Therapeutics, 2004 *''SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness.'' Friedman JS, Lopez MF, Fleming MD, Rivera A, Martin FM, Welsh ML, Boyd A, Doctrow SR, Burakoff SJ. Blood, 2004 *''Fratricide of CD8+ cytotoxic T lymphocytes is dependent on cellular activation and perforin-mediated killing.'' Su MW, Pyarajan S, Chang JH, Yu CL, Jin YJ, Stierhof YD, Walden P, Burakoff SJ. European Journal of Immunology, 2004 *''Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model.'' Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwitz D, Boyd A, Kupper TS, Burakoff SJ. Journal of the American Society of Blood and Marrow Transplantation, 2004 *''Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity.'' Slavik JM, Lim DG, Burakoff SJ, Hafler DA., Journal of Biological Chemistry, 2004

References

External links

Mount Sinai Hospital homepageThe Tisch Cancer Institute at Mount Sinai
{{DEFAULTSORT:Burakoff, Steven J. Albany Medical College alumni American medical academics Harvard Medical School alumni Lehigh University alumni Living people Queens College, City University of New York alumni Place of birth missing (living people) Year of birth missing (living people)