Sterol Carrier Protein
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Sterol carrier proteins (also known as nonspecific lipid transfer proteins) is a family of proteins that transfer
steroid A steroid is an organic compound with four fused compound, fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes t ...
s and probably also
phospholipid Phospholipids are a class of lipids whose molecule has a hydrophilic "head" containing a phosphate group and two hydrophobic "tails" derived from fatty acids, joined by an alcohol residue (usually a glycerol molecule). Marine phospholipids typ ...
s and
ganglioside A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. N-acetylneuraminic acid, ''N''-acetylneuraminic acid, NANA) linked on the sugar chain. NeuNAc, an acetylated derivative ...
s between cellular membranes. These proteins are different from plant nonspecific lipid transfer proteins but structurally similar to small proteins of unknown function from
Thermus thermophilus ''Thermus thermophilus'' is a gram stain, Gram-negative bacterium used in a range of biotechnological applications, including as a model organism for genetic manipulation, structural genomics, and systems biology. The bacterium is extremely therm ...
. This domain is involved in binding sterols. The human sterol carrier protein 2 ( SCP2) is a basic protein that is believed to participate in the intracellular transport of cholesterol and various other lipids.


Human proteins containing this domain

HSD17B4; HSDL2; SCP2; STOML1;


See also

*
Steroidogenic acute regulatory protein The steroidogenic acute regulatory protein, commonly referred to as StAR (STARD1), is a transport protein that regulates cholesterol transfer within the mitochondria, which is the rate-limiting step in the production of steroid hormones. It is ...
and START domain


References


External links


Sterol carrier proteins
in
SCOP A ( or ) was a poet as represented in Old English poetry. The scop is the Old English counterpart of the Old Norse ', with the important difference that "skald" was applied to historical persons, and scop is used, for the most part, to designat ...

SCP-2 sterol transfer family
in Pfam * * Peripheral membrane proteins Protein domains Protein families Water-soluble transporters {{membrane-protein-stub