(−)-Stepholidine is a proto
berberine alkaloid found in the plant ''
Stephania intermedia''.
Stepholidine activity includes dual
D2 receptor antagonist
An antagonist is a character in a story who is presented as the chief foe of the protagonist.
Etymology
The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, riv ...
and
D1 receptor agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
, and has shown
antipsychotic activity in animal studies.
See also
References
D1-receptor agonists
D2 antagonists
Benzylisoquinoline alkaloids
Phenols
Phenol ethers
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