A splicing factor is a protein involved in the removal of

introns An intron is any Nucleic acid sequence, nucleotide sequence within a gene that is not expressed or operative in the final RNA product. The word ''intron'' is derived from the term ''intragenic region'', i.e., a region inside a gene."The notion of ...

from strings of

messenger RNA In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein. mRNA is created during the ...

, so that the

exons An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. The term ''exon'' refers to both the DNA sequence within a gene and to the corresponding sequence i ...

can bind together; the process takes place in particles known as spliceosomes. Splicing factors regulate the binding of the snRNPs U1 and U2 to the 3' and 5' ends of the intron during splicing and can either be splicing promoters or splicing repressors.> In a research paper, splicing factors were found to be produced upon application of

resveratrol Resveratrol (3,5,4′-trihydroxy-''trans''-stilbene) is a stilbenoid, a type of natural phenol or polyphenol and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacterium, ba ...

analogues, which induced senescent cells to rejuvenate. The expression of splicing factors may be altered during aging.

Splicing factor 3b

Splicing factor 3b is a

protein complex A protein complex or multiprotein complex is a group of two or more associated polypeptide chains. Protein complexes are distinct from multidomain enzymes, in which multiple active site, catalytic domains are found in a single polypeptide chain. ...

consisting of the following proteins: PHF5A,

SF3B1 Splicing factor 3B subunit 1 is a protein that in humans is encoded by the ''SF3B1'' gene. Function This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and U2 spliceosom ...

, SF3B2, SF3B3,

SF3B4 Splicing factor 3B subunit 4 is a protein that in humans is encoded by the ''SF3B4'' gene. Function This gene encodes one of four subunits of the splicing factor 3b. The protein encoded by this gene cross-links to a region in the pre-mRNA imm ...

, SF3B5, SF3B6.

Notes

Biochemistry Spliceosome Ageing {{protein-stub