Spleen exonuclease (, ''3'-exonuclease'', ''spleen phosphodiesterase'', ''3'-nucleotide phosphodiesterase'', ''phosphodiesterase II'') is an

enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

. This enzyme catalyses the following

chemical reaction A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...

Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates (exonuclease type b)

This enzyme has a preference for single-stranded substrate.

PLD3 Phospholipase D3, also known as PLD3, is a protein that in humans is encoded by the ''PLD3'' gene. PLD3 belongs to the phospholipase D superfamily because it contains the two HKD motifs common to members of the phospholipase D family, however, i ...

and/or

PLD4 Phospholipase D family member 4 is an enzyme that in humans is encoded by the PLD4 gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that ...

might be the genes encoding spleen exonuclease, as they have similar substrate specificity and tissue distribution.

References

External links

* EC 3.1.16 {{Enzyme-stub