Spirapril, sold under the brand name Renormax among others, is an

ACE inhibitor Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of high blood pressure and heart failure. They work by causing relaxation of blood vessels as well as a decrease in blood volum ...

antihypertensive Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that ...

drug used to treat hypertension. It belongs to dicarboxy group of ACE inhibitors. It was patented in 1980 and approved for medical use in 1995.

Chemistry

Like many ACE inhibitors, this prodrug is converted to the active metabolite spiraprilat following oral administration. Unlike other members of the group, it is eliminated both by renal and hepatic routes, which may allow for greater use in patients with renal impairment. However, data on its effect upon the

renal function Assessment of kidney function occurs in different ways, using the presence of symptoms and signs, as well as measurements using urine tests, blood tests, and medical imaging. Functions of a healthy kidney include maintaining a person's fluid b ...

are conflicting.

References

External links

* ACE inhibitors Carboxamides Enantiopure drugs Ethyl esters Nitrogen heterocycles Prodrugs Spiro compounds Dithiolanes {{cardiovascular-drug-stub