Smoothelin is a
protein that in humans is encoded by the ''SMTN''
gene.
This gene encodes a
structural protein that is found exclusively in contractile
smooth muscle
Smooth muscle is an involuntary non-striated muscle, so-called because it has no sarcomeres and therefore no striations (''bands'' or ''stripes''). It is divided into two subgroups, single-unit and multiunit smooth muscle. Within single-unit mus ...
cells. It associates with stress fibers and constitutes part of the
cytoskeleton. This gene is localized to
chromosome 22q12.3, distal to the TUPLE1 locus and outside the
DiGeorge syndrome deletion.
Alternative splicing
Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to code for multiple proteins. In this process, particular exons of a gene may be ...
of this gene results in three transcript variants.
References
Further reading
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