Signum Biosciences, Inc. is a

dietary supplement A dietary supplement is a manufactured product intended to supplement a person's diet by taking a pill (pharmacy), pill, capsule (pharmacy), capsule, tablet (pharmacy), tablet, powder, or liquid. A supplement can provide nutrients eithe ...

company located in Boulder, Colorado.

History

Signum was founded in 2003 by Maxwell Stock and his father Jeffrey B. Stock in Monmouth Junction, NJ. In 2020 the company relocated to Boulder, Colorado. Signum agreed in 2019 to stop making certain claims about its ''EHT'' supplement, and to stop allowing its

multi-level marketing Multi-level marketing (MLM), also called network marketing or pyramid selling, is a controversial and sometimes illegal marketing strategy for the sale of products or services in which the revenue of the MLM company is derived from a non-salarie ...

partner firm Neora (formerly Nerium International) to make such claims.

Neora (Nerium) partnership and FTC injunction

In 2015 Signum partnered with Neora, LLC (then known as Nerium International) to launch a

called eicosanoyl-5-hydroxytryptamide (EHT). EHT is derived from coffee and inhibits demethylation of the enzyme

protein phosphatase 2 Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the ''PPP2CA'' gene. The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in ...

(PPP2CA; PP2A). In October 2019 the

Federal Trade Commission The Federal Trade Commission (FTC) is an independent agency of the United States government whose principal mission is the enforcement of civil (non-criminal) United States antitrust law, antitrust law and the promotion of consumer protection. It ...

won a permanent injunction against Signum BioSciences, Signum Nutralogix, and affiliated companies including Neora. The injunction prohibits claims or representations of EHT's efficacy in treating or mitigating

Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems wit ...

Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become ...

, or brain injury including CTE and

concussion A concussion, also known as a mild traumatic brain injury (mTBI), is a head injury that temporarily affects brain functioning. Symptoms may include headache, dizziness, difficulty with thinking and concentration, sleep disturbances, a brief ...

, unless those claims are backed up by randomized, double-blind, placebo-controlled human clinical testing.

External links

Company site

References

{{reflist Biotechnology companies of the United States 2003 establishments in New Jersey Multi-level marketing products Federal Trade Commission litigation