Siamon Gordon (born 29 April 1938) is a British

pathologist Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in t ...

. He is Glaxo Wellcome

Professor Emeritus ''Emeritus'' (; female: ''emerita'') is an adjective used to designate a retired chair, professor, pastor, bishop, pope, director, president, prime minister, rabbi, emperor, or other person who has been "permitted to retain as an honorary title ...

Cellular Pathology Cytopathology (from Greek , ''kytos'', "a hollow"; , ''pathos'', "fate, harm"; and , ''-logia'') is a branch of pathology that studies and diagnoses diseases on the cellular level. The discipline was founded by George Nicolas Papanicolaou in 1 ...

at the

University of Oxford The University of Oxford is a collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the world's second-oldest university in contin ...

Education

He gained his medical degrees ( M.B. and

Ch.B. Bachelor of Medicine, Bachelor of Surgery ( la, Medicinae Baccalaureus, Baccalaureus Chirurgiae; abbreviated most commonly MBBS), is the primary medical degree awarded by medical schools in countries that follow the tradition of the United Kin ...

) from the

University of Cape Town The University of Cape Town (UCT) ( af, Universiteit van Kaapstad, xh, Yunibesithi ya yaseKapa) is a public research university in Cape Town, South Africa. Established in 1829 as the South African College, it was granted full university statu ...

South Africa South Africa, officially the Republic of South Africa (RSA), is the southernmost country in Africa. It is bounded to the south by of coastline that stretch along the South Atlantic and Indian Oceans; to the north by the neighbouring count ...

. He earned his

PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * ''Piled Higher and Deeper ''Piled Higher and Deeper'' (also known as ''PhD Comics''), is a newsp ...

from

Rockefeller University The Rockefeller University is a Private university, private Medical research, biomedical Research university, research and graduate-only university in New York City, New York (state), New York. It focuses primarily on the biological and medica ...

, where he taught from 1971 to 1976. The rest of his career, from 1976 to 2008, was at the University of Oxford.

Career and research

He was on the

Faculty of 1000 F1000 (formerly "Faculty of 1000") is an open research publisher for scientists, scholars, and clinical researchers. F1000 offers a different research evaluation service from standard academic journals by offering peer-review after, rather than ...

. He was a visiting scientist at the

NIH The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1 ...

. He is on the Scientific Advisory Board of the

American Asthma Foundation The American Asthma Foundation (AAF) was a non-profit grant program that funds basic research focused on asthma Asthma is a long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptom ...

. Gordon is noted for his work on the phenotypic and functional diversity of

macrophages Macrophages (abbreviated as M φ, MΦ or MP) ( el, large eaters, from Greek ''μακρός'' (') = large, ''φαγεῖν'' (') = to eat) are a type of white blood cell of the immune system that engulfs and digests pathogens, such as cancer ce ...

. He began his studies on macrophages while in the laboratory of

Zanvil Cohn Zanvil Alexander Cohn (November 16, 1926 – June 28, 1993) was a cell biologist and immunologist who upon his death was described by ''The New York Times'' as being "in the forefront of current studies of the body's defenses against infection.", ...

in 1966. Upon his move to the

Sir William Dunn School of Pathology The Sir William Dunn School of Pathology is a department within the University of Oxford. Its research programme includes the cellular and molecular biology of pathogens, the immune response, cancer and cardiovascular disease. It teaches undergra ...

in 1976 he continued this work and identified the pan- macrophage marker

F4/80 EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ''ADGRE1'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units ...

. Subsequent studies led to the identification of various scavenger receptors and the

cloning Cloning is the process of producing individual organisms with identical or virtually identical DNA, either by natural or artificial means. In nature, some organisms produce clones through asexual reproduction. In the field of biotechnology, c ...

of the

pattern recognition receptor Pattern recognition receptors (PRRs) play a crucial role in the proper function of the innate immune system. PRRs are germline-encoded host sensors, which detect molecules typical for the pathogens. They are proteins expressed, mainly, by cells of ...

, Dectin-1.

Publications

*''Macrophage Biology and Activation, Current Topics in Microbiology and Immunology'' (ed, 1992) * Siamon Gordon (ed) ''The Legacy of cell fusion'' Oxford University Press, 1994, *''Advances in Cell and Molecular Biology of Membranes and Organelles'' (ed, 1999) *Siamon Gordon, ed (1999). ''Phagocytosis: the host'' 5. JAI Press, * * *

References

{{DEFAULTSORT:Gordon, Siamon British pathologists Fellows of Exeter College, Oxford Fellows of the Royal Society Fellows of the Academy of Medical Sciences (United Kingdom) Statutory Professors of the University of Oxford University of Cape Town alumni Rockefeller University alumni Living people 1938 births