Sheila Sue David is an American chemist who is a professor at the

University of California, Davis The University of California, Davis (UC Davis, UCD, or Davis) is a Public university, public Land-grant university, land-grant research university in Davis, California, United States. It is the northernmost of the ten campuses of the University ...

. Her research uses chemical approaches to understand cellular mechanisms, including

DNA repair DNA repair is a collection of processes by which a cell (biology), cell identifies and corrects damage to the DNA molecules that encode its genome. A weakened capacity for DNA repair is a risk factor for the development of cancer. DNA is cons ...

. She focuses on the repair of damaged DNA bases, which is mediated by base excision repair. She is a Fellow of the

American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all ...

and

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is a United States–based international nonprofit with the stated mission of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsib ...

Early life and education

David became interested in

DNA Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...

as a child, when she explored the laws of

Mendelian inheritance Mendelian inheritance (also known as Mendelism) is a type of biological inheritance following the principles originally proposed by Gregor Mendel in 1865 and 1866, re-discovered in 1900 by Hugo de Vries and Carl Correns, and later popularize ...

by breeding mice in fifth grade. She converted one of the rooms in her house into a science laboratory. She became interested in biochemistry during her undergraduate degree at

St. Olaf College St. Olaf College is a private liberal arts college in Northfield, Minnesota, United States. It was founded in 1874 by a group of Norwegian-American pastors and farmers led by Pastor Bernt Julius Muus. The college is named after the King and th ...

, where she discovered structure-function relationships. David moved to the

University of Minnesota The University of Minnesota Twin Cities (historically known as University of Minnesota) is a public university, public Land-grant university, land-grant research university in the Minneapolis–Saint Paul, Twin Cities of Minneapolis and Saint ...

for graduate studies, where she investigated inhibitor binding to uteroferrin, completing her doctorate in 1990 under the supervision of Lawrence Que Jr. Next, David moved to

California Institute of Technology The California Institute of Technology (branded as Caltech) is a private research university in Pasadena, California, United States. The university is responsible for many modern scientific advancements and is among a small group of institutes ...

as an

National Institutes of Health The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...

Postdoctoral Fellow.

Research and career

David worked as an assistant and associate professor in Santa Cruz and

Utah Utah is a landlocked state in the Mountain states, Mountain West subregion of the Western United States. It is one of the Four Corners states, sharing a border with Arizona, Colorado, and New Mexico. It also borders Wyoming to the northea ...

before joining the

in 2006. Her research uses the tools of chemical biology to explore the mechanistic details of DNA repair. DNA is damaged by reactive oxygen species (e.g. the hydroxyl radical), and biological organisms have evolved various strategies for regeneration and repair. In particular, she studies the proteins

MUTYH ''MUTYH'' (mutY DNA glycosylase) is a human gene that encodes a DNA glycosylase, MUTYH glycosylase. It is involved in oxidative DNA damage repair and is part of the base excision repair pathway. The enzyme excises adenine bases from the DNA backbo ...

and

NEIL1 Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the ''NEIL1'' gene. NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by ...

, which help to catalyze the repair of damaged DNA as part of the

base excision repair Base excision repair (BER) is a cellular mechanism, studied in the fields of biochemistry and genetics, that repairs damaged DNA throughout the cell cycle. It is responsible primarily for removing small, non-helix-distorting base lesions from t ...

pathway. MUTYH is a glycosylase that identifies and cleaves mismatched nucleobases, which triggers DNA repair. David is interested in how MUTYH locates the appropriate damaged target amidst the naturally occurring healthy DNA, as this may have implications in cancer therapeutics and drug discovery.

Awards and honors

Fellow *

Alfred P. Sloan Foundation The Alfred P. Sloan Foundation is an American philanthropic nonprofit organization. It was established in 1934 by Alfred P. Sloan Jr., president and chief executive officer of General Motors. The Sloan Foundation makes grants to support origina ...

Fellow * Editor of ''

DNA Repair DNA repair is a collection of processes by which a cell (biology), cell identifies and corrects damage to the DNA molecules that encode its genome. A weakened capacity for DNA repair is a risk factor for the development of cancer. DNA is cons ...

'' * Environmental Mutagenesis and Genomics Society Education Award

Selected publications

* * *

References

{{DEFAULTSORT:David, Sheila Living people Year of birth missing (living people) St. Olaf College alumni University of Minnesota alumni University of California, Davis faculty 20th-century American chemists 21st-century American chemists American women chemists Fellows of the American Chemical Society Fellows of the American Association for the Advancement of Science