Shane Patrick Crotty (born 26 January 1974) is a professor of

immunology Immunology is a branch of biology and medicine that covers the study of Immune system, immune systems in all Organism, organisms. Immunology charts, measures, and contextualizes the Physiology, physiological functioning of the immune system in ...

in the Center for Infectious Disease and Vaccine Research at the La Jolla Institute for Immunology.

Education and academic posts

Crotty completed B.S. degrees in Biology and Writing from

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a Private university, private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of moder ...

in 1996. He then completed his Ph.D. in 2001 at the

University of California, San Francisco The University of California, San Francisco (UCSF) is a Public university, public Land-grant university, land-grant research university in San Francisco, California, United States. It is part of the University of California system and is dedic ...

with

Raul Andino Raul Andino is a virologist and professor in the Department of Microbiology and Immunology at the University of California, San Francisco. He is noted for leading a team of researchers that developed the first new oral polio vaccine in 50 years. ...

. Crotty went on to a

postdoctoral fellowship A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary academ ...

from 2001 to 2003 with Rafi Ahmed at Emory University Vaccine Center studying immunity to viruses. He joined the La Jolla Institute for Immunology (LJI) in 2003, as well as the department of medicine of

University of California, San Diego The University of California, San Diego (UC San Diego in communications material, formerly and colloquially UCSD) is a public university, public Land-grant university, land-grant research university in San Diego, California, United States. Es ...

, in 2004 as an adjunct assistant professor. He became an associate member with tenure at LJI in 2009, and then a tenured professor.

Research

Crotty's research has focused on immune responses to viral infections, in particular those driven by vaccines. His lab has done major work on the regulation and proliferation of follicular helper T cells, as well as immunological protection from

HIV The human immunodeficiency viruses (HIV) are two species of '' Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the im ...

infection and HIV vaccine delivery strategy. In close collaboration with

Alessandro Sette Alessandro Sette is an Italian immunologist. He was born on August 11, 1960, in Rome, Italy, to :it:Pietro Sette, Pietro Sette, a prominent Italian businessman and politician, and Renata Sette. Sette is a professor at the La Jolla Institute for I ...

, Crotty published the first detailed analysis of the human immune response to SARS-CoV-2, the virus that causes COVID-19, and later confirmed that the

adaptive immune response The adaptive immune system (AIS), also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized cells, organs, and processes that eliminate pathogens specifically. The ac ...

is lasting. In 2020, Crotty joined the LJI Coronavirus Taskforce to study immune system responses with an aim of informing vaccines and therapies against the novel coronavirus,

SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19, the respiratory illness responsible for the COVID-19 pandemic. The virus previously had the Novel coronavirus, provisional nam ...

. His lab studies the adaptive immune response against SARS-CoV-2. In May 2020, his lab co-published the first detailed analysis of how the immune system responds to SARS-CoV-2, with LJI Professor

. This research suggested that the human body may be capable of long-term immunity to SARS-CoV-2 following infection or vaccine administration. Crotty has since published research showing that "uncoordinated" immune cell responses are related to COVID-19 case severity. His lab has also collaborated with Sette to show that T cells that react to common cold coronaviruses can also recognize SARS-CoV-2. Crotty has warned that this T-cell immunity does not equal protection against the virus.

Major publications

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Other publications

Crotty is also the author of a biography of

David Baltimore David Baltimore (born March 7, 1938) is an American biologist, university administrator, and 1975 Nobel Prize in Physiology or Medicine, Nobel laureate in Physiology or Medicine. He is a professor of biology at the California Institute of Tech ...

entitled ''Ahead of the Curve''. He is the co-editor with Rafi Ahmed of ''Immune Memory and Vaccines: Great Debates''.

References

External links

* {{DEFAULTSORT:Crotty, Shane 1974 births Living people Massachusetts Institute of Technology alumni University of California, San Francisco alumni American immunologists American virologists