Setiptiline (brand name Tecipul), also known as teciptiline, is a

tetracyclic antidepressant Tetracyclic antidepressants (TeCAs) are a class of antidepressants that were first introduced in the 1970s. They are named after their tetracyclic chemical structure, containing four rings of atoms, and are closely related to the tricyclic ant ...

(TeCA) that acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It was launched in 1989 for the treatment of depression in Japan by Mochida.

Pharmacology

Pharmacodynamics

Setiptiline acts as a

norepinephrine reuptake inhibitor A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epine ...

, α₂-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT₂ subtypes, as well as an H₁ receptor

inverse agonist In pharmacology, an inverse agonist is a drug that binds to the same receptor as an agonist but induces a pharmacological response opposite to that of the agonist. A neutral antagonist has no activity in the absence of an agonist or inverse ag ...

antihistamine Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provide ...

Chemistry

Setiptiline has a

tetracyclic Tetracyclics are cyclic chemical compounds that contain four interconnected rings of atoms, e.g. Tröger's base. They have various pharmaceutical uses, for instance the tetracycline antibiotics and the tetracyclic antidepressants. See also * ...

structure and is a close analogue of

mianserin Mianserin, sold under the brand name Tolvon among others, is an atypical antidepressant that is used primarily in the treatment of depression in Europe and elsewhere in the world. It is a tetracyclic antidepressant (TeCA). Mianserin is close ...

and

mirtazapine Mirtazapine, sold under the brand name Remeron amongst others, is an atypical antidepressant, and as such is used primarily to treat depression. Its effects may take up to four weeks, but can also manifest as early as one to two weeks. It is ...

, with setiptiline being delta(13b,4a),4a-carba-mianserin, and mirtazapine being 6-azamianserin.

References

Alpha-2 blockers H1 receptor antagonists Noradrenergic and specific serotonergic antidepressants Piperidines Serotonin receptor antagonists Tetracyclic antidepressants {{nervous-system-drug-stub