Serratiopeptidase (Serratia E-15 protease, also known as serralysin, serrapeptase, serratiapeptase, serratia peptidase, serratio peptidase, or serrapeptidase) is a proteolytic enzyme (protease) produced by enterobacterium ''Serratia'' sp. E-15, now known as ''

Serratia marcescens ''Serratia marcescens'' () is a species of rod-shaped, Gram-negative bacteria in the family Yersiniaceae. It is a facultative anaerobe and an opportunistic pathogen in humans. It was discovered in 1819 by Bartolomeo Bizio in Padua, Italy.Serra ...

'' ATCC 21074. This microorganism was originally isolated in the late 1960s from

silkworm The domestic silk moth (''Bombyx mori''), is an insect from the moth family Bombycidae. It is the closest relative of '' Bombyx mandarina'', the wild silk moth. The silkworm is the larva or caterpillar of a silk moth. It is an economically ...

(''Bombyx mori'' L.) intestine.The preparation and some uses of the protease are described in . The enzyme was also described by and the strain of bacteria producing serratiopeptidase has been deposited with the

American Type Culture Collection ATCC or the American Type Culture Collection is a nonprofit organization which collects, stores, and distributes standard reference microorganisms, cell lines and other materials for research and development. Established in 1925 to serve as a natio ...

as strain ATCC 21074. (For online information about ATCC 21074, enter 21074 o
the ATCC/LGC search page
Serratiopeptidase is present in the silkworm intestine and allows the emerging moth to dissolve its cocoon. Serratiopeptase is produced by purification from culture of Serratia E-15 bacteria. It is a member of the Peptidase M10B (Matrixin) family.

Health claims

Some

alternative medicine Alternative medicine is any practice that aims to achieve the healing effects of medicine despite lacking biological plausibility, testability, repeatability, or evidence from clinical trials. Complementary medicine (CM), complementary and ...

proponents claim that serratiopeptidase is beneficial for pain and inflammation, but "existing trials

ave been ''Alta Velocidad Española'' (''AVE'') is a service of high-speed rail in Spain operated by Renfe, the Spanish national railway company, at speeds of up to . As of December 2021, the Spanish high-speed rail network, on part of which the AVE ...

small and generally of poor methodological quality." Online

medical journal A medical journal is a peer-reviewed scientific journal that communicates medical information to physicians, other health professionals. Journals that cover many medical specialties are sometimes called general medical journals. History The first ...

Bandolier A bandolier or a bandoleer is a pocketed belt for holding either individual bullets, or belts of ammunition. It is usually slung sash-style over the shoulder and chest, with the ammunition pockets across the midriff and chest. Though functio ...

'' (specializing in evidence-based thinking about healthcare) published an article (in about 2001) in response to a reader's enquiry about serratiopeptidase. After searching

PubMed PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintain ...

and the

Cochrane Library The Cochrane Library (named after Archie Cochrane) is a collection of databases in medicine and other health care, healthcare specialties provided by Cochrane (organisation), Cochrane and other organizations. At its core is the collection of Coc ...

"to see if there are any randomised, controlled trials", the article stated that the "evidence on serratiopeptidase being effective for anything is not based on a firm foundation of clinical trials." The search found 34 publications in the medical databases covered that addressed the efficacy of serratiopeptidase, of which several were found to be animal experiments, personal letters, uncontrolled trials or those with inadequate or nonexistent randomisation. The article warned against ignoring safety issues with use of biological agents. No studies were found to have been conducted on the efficacy of serratiopeptidase as treatment for back pain, heart attack, stroke, or asthma. Of the 10 medical conditions with randomized-evidence studies on file in connection with serratiopeptidase, the quality or construction of the trial studies was described as "generally poor".According to Bandolier:

References

External links

* The

MEROPS MEROPS is an online database for peptidases (also known as proteases, proteinases and proteolytic enzymes) and their inhibitors. The classification scheme for peptidases was published by Rawlings & Barrett in 1993, and that for protein inhibi ...

online database for peptidases and their inhibitors
M10.051
{{Portal bar, Biology, border=no Biologically-based therapies Proteases EC 3.4.24

Health claims

See also

References

External links