Sergliflozin etabonate (

INN Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway; before the advent of motorized transportation they also provided accommo ...

USAN 280px, "Samguk Sagi" Book 04. Silla's Records. In 512, Usan-guk（于山國）was Ulleungdo（鬱陵島） Usan-guk, or the State of Usan, occupied Ulleung-do and the adjacent islands during the Korean Three Kingdoms period. According to the ...

, codenamed GW869682X) is an investigational

anti-diabetic drug Drugs used in diabetes treat diabetes mellitus by altering the glucose level in the blood. With the exceptions of insulin, most GLP receptor agonists ( liraglutide, exenatide, and others), and pramlintide, all are administered orally and are t ...

being developed by

GlaxoSmithKline GSK plc, formerly GlaxoSmithKline plc, is a British Multinational corporation, multinational pharmaceutical and biotechnology company with global headquarters in London, England. Established in 2000 by a Mergers and acquisitions, merger of Gl ...

. It did not undergo further development after phase II.

Method of action

Sergliflozin inhibits subtype 2 of the

sodium-glucose transport proteins Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa ( enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron ( SGL ...

(SGLT2), which is responsible for at least 90% of the glucose

reabsorption In renal physiology, reabsorption or tubular reabsorption is the process by which the nephron removes water and solutes from the tubular fluid (pre-urine) and returns them to the circulating blood. It is called ''reabsorption'' (and not ''absorp ...

in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine.Prous Science: Molecule of the Month November 2007
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Chemistry

Etabonate Etabonate or ethyl carbonate is the chemical group with formula –, or –. The names are also used for esters R–, for the anion [], and for salt (chemistry), salts of the latter. Pharmaceutical aspects "Etabonate" is an international no ...

'' refers to the ethyl carbonate group. The remaining structure, which is the active substance, is called ''sergliflozin''. Sergliflozin skeletal

References

SGLT2 inhibitors Glucosides Prodrugs Phenol ethers Abandoned drugs {{gastrointestinal-drug-stub