Senotherapeutics refers to therapeutic agents/strategies that specifically target

cellular senescence Cellular senescence is a phenomenon characterized by the cessation of cell division. In their experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of appro ...

. Senotherapeutics include emerging

senolytic A senolytic (from the words ''senescence'' and ''-lytic'', "destroying") is among a class of small molecules under basic research to determine if they can selectively induce death of senescent cells and improve health in humans. A goal of this r ...

/senoptotic small molecules that specifically induce cell death in senescent cells and agents that inhibit the pro-inflammatory senescent secretome. Senescent cells can be targeted for immune clearance, but an ageing immune system likely impairs senescent cell clearance leading to their accumulation.Burton and Faragher (2015)
Cellular senescence: from growth arrest to immunogenic conversion
AGE Therefore, agents which can enhance immune clearance of senescent cells can also be considered as senotherapeutic.

References

{{Reflist Senescence