Selisistat (EX-527) is an experimental drug which is a potent and selective inhibitor of the
SIRT1 protein. It was developed as a potential agent for the treatment of
Huntington's disease
Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease that is mostly Genetic disorder#Autosomal dominant, inherited. It typically presents as a triad of progressive psychiatric, cognitive, and ...
, but also has potential applications in
cancer
Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Po ...
treatment.
References
{{reflist
Experimental drugs
Amides
Chlorobenzenes
Tetrahydrocarbazoles