Sebaceous adenomais a type of
adenoma
An adenoma is a benign tumor of epithelium, epithelial tissue with glandular origin, glandular characteristics, or both. Adenomas can grow from many glandular organ (anatomy), organs, including the adrenal glands, pituitary gland, thyroid, prosta ...
, characterized by a slow-growing
tumor
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...
usually presenting as a pink, flesh-coloured, or yellow
papule
A papule is a small, well-defined bump in the skin lesion, skin. It may have a rounded, pointed or flat top, and may have a umbilication, dip. It can appear with a Peduncle (anatomy), stalk, be thread-like or look warty. It can be soft or firm a ...
or
nodule
Nodule may refer to:
* Nodule (geology), a small rock or mineral cluster
* Manganese nodule, a metallic concretion found on the seafloor
*Nodule (medicine), a small aggregation of cells
*Root nodule
Root nodules are found on the roots of plants, ...
.
[ James et al. 2006][ Rapini et al. 2007]
Significance
Sebaceous adenomas, in isolation, are not significant; however, they may be associated with
Muir-Torre syndrome, a
genetic condition
A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosome abnormality. Although polygenic disorders are ...
that predisposes individuals to
cancer
Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Po ...
. It is also linked to
hereditary nonpolyposis colorectal cancer
Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.
HNPCC includes (and was once synonymous with) Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon ...
(Lynch syndrome).
It is not the same as "
adenoma sebaceum" by
F. Balzer and
P.E. Ménétrier (1885). The term "adenoma sebaceum" is a misnomer for ''facial angiofibromas'' associated with
tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin. A combinatio ...
.
[ Morgan et al. 1979]
See also
*
Sebaceous carcinoma
*
Sebaceous hyperplasia
*
List of cutaneous conditions
Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the Human body, body and composed of Human skin, skin, hair, Nail (anatomy), nails, and related muscle and glands. The major function o ...
*
List of cutaneous neoplasms associated with systemic syndromes
Notes
References
Sources
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External links
{{Tumors of skin appendages
Epidermal nevi, neoplasms, and cysts