The Saville reaction is a chemical reaction in which
mercury replaces a
nitrosyl from a
thiol
In organic chemistry, a thiol (; ), or thiol derivative, is any organosulfur compound of the form , where R represents an alkyl or other organic substituent. The functional group itself is referred to as either a thiol group or a sulfhydryl grou ...
group.
It is used as a method of replacing the nitrosyl from the modified
cysteine
Cysteine (; symbol Cys or C) is a semiessential proteinogenic amino acid with the chemical formula, formula . The thiol side chain in cysteine enables the formation of Disulfide, disulfide bonds, and often participates in enzymatic reactions as ...
s and thus can serve in research of the redox modification of different proteins.
[A scheme for the colorimetric determination of microgram amounts of thiols; Saville B. Analyst 83, 670 (1958) PN50818.]
References
External links
On use of Saville Reactions on Invitrogen page
Name reactions
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