Sauvagine is a

neuropeptide Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like th ...

from the corticotropin-releasing factor (CRF) family of peptides and is

orthologous Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a spe ...

to the mammalian hormone, urocortin 1, and the

teleost Teleostei (; Greek ''teleios'' "complete" + ''osteon'' "bone"), members of which are known as teleosts ), is, by far, the largest infraclass in the class Actinopterygii, the ray-finned fishes, containing 96% of all extant species of fish. Tel ...

fish hormone, urotensin 1. It is 40 amino acids in length, and has the sequence XGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2, with a pyrrolidone carboxylic acid modification at the N-terminal and amidation of the C-terminal isoleucine residue. It was originally isolated from the skin of the frog '' Phyllomedusa sauvagii.'' Given its relation to other CRF-related peptides, it exerts similar physiological effects as

corticotropin-releasing hormone Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in stress responses. It is a releasing hormone that bel ...

. Sauvagine belongs to the corticotropin-releasing factor (CRF) family that also includes

CRF CRF may refer to: Science and technology * Corticotropin-releasing factor family, a family of related neuropeptides in vertebrates ** Corticotropin-releasing hormone or corticotropin-releasing factor, a polypeptide hormone * Chromatographic respons ...

, urocortin l/urotensin l, urocortin II and urocortin III.

Interactions

Sauvagine has been shown to interact with corticotropin releasing factor receptors 1 and 2, and (as with other CRF-related peptides) is also bound by the corticotropin-releasing factor binding protein.

References

Corticotropin-releasing hormone receptor agonists Peptide hormones {{biochem-stub