Santo is a masculine given name which may refer to:

People

* Santo Biasatti (born 1943), Argentine journalist * Santo Cilauro (born 1961), Australian comedian, actor, and television producer * Santo Condorelli (born 1995), Italian swimmer * Santo Farina (born 1937), American rock and roll musician * Santo Jeger (1898–1953), British politician * Santo Loquasto (born 1944), American production, set and costume designer * Santo Mazzarino (1916–1987), Italian historian * Santo Santoro (born 1956), Australian politician * Santo Stephens (born 1969), American football player * Santo Trafficante Jr. (1914–1987), American Mafia boss, head of the Trafficante crime family * Santo Trafficante Sr. (1886–1954), Sicilian-born mobster, father of the above * Santo Versace (born 1944), Italian businessman and politician

Fictional characters

* Rockslide (Santo Vaccarro), Marvel Comics character {{given name Masculine given names