Samuel M. Seidlin (1 May 1895 - 1955) was Russian-born American endocrinologist who pioneered the field of by using

radioiodine There are 37 known isotopes of iodine (53I) from 108I to 144I; all undergo radioactive decay except 127I, which is stable. Iodine is thus a monoisotopic element. Its longest-lived radioactive isotope, 129I, has a half-life of 15.7 million year ...

for diagnosis and therapy of

thyroid cancer Thyroid cancer is cancer that develops from the tissues of the thyroid gland. It is a disease in which cells grow abnormally and have the potential to spread to other parts of the body. Symptoms can include swelling or a lump in the neck. C ...

during the early 1940s.

Early life

Samuel Seidlin was born in

Dnipropetrovsk Oblast Dnipropetrovsk Oblast ( uk, Дніпропетро́вська о́бласть, translit=Dnipropetrovska oblast), also referred to as Dnipropetrovshchyna ( uk, Дніпропетро́вщина), is an oblast (province) of central-eastern Ukra ...

Ukraine Ukraine ( uk, Україна, Ukraïna, ) is a country in Eastern Europe. It is the second-largest European country after Russia, which it borders to the east and northeast. Ukraine covers approximately . Prior to the ongoing Russian invas ...

, to Martin S Seidlin and Sima Seidlin. He was brought to

New York City New York, often called New York City or NYC, is the most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the most densely populated major city in the U ...

as a child. He earned his MD in 1923 at Columbia University Vagelos College of Physicians and Surgeon''s'' and served as an intern and junior staff member at

Johns Hopkins Hospital The Johns Hopkins Hospital (JHH) is the teaching hospital and biomedical research facility of the Johns Hopkins School of Medicine, located in Baltimore, Maryland, U.S. It was founded in 1889 using money from a bequest of over $7 million (1873 ...

Baltimore Baltimore ( , locally: or ) is the List of municipalities in Maryland, most populous city in the U.S. state of Maryland, fourth most populous city in the Mid-Atlantic (United States), Mid-Atlantic, and List of United States cities by popula ...

Career

Seidlin established the Medical Physics Research Laboratory at Montefiore Hospital and its Endocrine Clinic in 1943. In the same year, at Montefiore Hospital in

, building on the success of Dr

Saul Hertz Saul Hertz, M.D. (April 20, 1905 – July 28, 1950) was an American physician who devised the medical uses of radioactive iodine. Hertz pioneered the first targeted cancer therapies. Hertz is called the father of the field of theranostics, combin ...

's use of radioactive iodine to treat

Graves' Disease Graves' disease (german: Morbus Basedow), also known as toxic diffuse goiter, is an autoimmune disease that affects the thyroid. It frequently results in and is the most common cause of hyperthyroidism. It also often results in an enlarged thyr ...

, Seidlin consulted with Dr. Hertz regarding the use of RAI in the treatment of thyroid carcinoma. Dr Seidlin administered

to a patient, and used the radioisotope to locate the several

metastases Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, the ...

from adenocarcinoma of the thyroid. Seidlin continued as chief of the Endocrine Clinic and the Medical Physics Research Laboratory at Montefiore and treated 23 patients for metastatic thyroid cancer with radioiodine, utilizing from reactors for most of them.

References

Sources

# # # # {{DEFAULTSORT:Seidlin, Samuel 1895 births 1955 deaths Emigrants from the Russian Empire to the United States American endocrinologists Columbia University Vagelos College of Physicians and Surgeons alumni 20th-century American physicians People from Dnipropetrovsk Oblast