Salvinorin B methoxymethyl ether (2-''O''-methoxymethylsalvinorin B) is a semi-synthetic
analogue of the natural product
salvinorin A
Salvinorin A is the main active psychotropic molecule in '' Salvia divinorum''. Salvinorin A is considered an atypical dissociative hallucinogen.
It is structurally distinct from other naturally occurring hallucinogens (such as DMT, psil ...
used in scientific research.
It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A,
and has increased affinity and potency at the
κ-opioid receptor
Receptor may refer to:
* Sensory receptor, in physiology, any neurite structure that, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and respond ...
. It is prepared from
salvinorin B
Salvinorin A is the main active psychotropic molecule in ''Salvia divinorum''. Salvinorin A is considered an atypical dissociative hallucinogen.
It is structurally distinct from other naturally occurring hallucinogens (such as DMT, psilocy ...
.
The
crystal structure
In crystallography, crystal structure is a description of ordered arrangement of atoms, ions, or molecules in a crystalline material. Ordered structures occur from intrinsic nature of constituent particles to form symmetric patterns that repeat ...
is almost superimposable with that of salvinorin A. Structures bound to the κ-opioid receptor have also been reported.
Salvinorin B methoxymethyl ether has a
Ki of 0.60 nM at the κ opioid receptor,
and is around five times more potent than salvinorin A in animal studies, although it is still only half as potent as its ethoxymethyl ether
homolog
In biology, homology is similarity in anatomical structures or genes between organisms of different taxa due to shared ancestry, ''regardless'' of current functional differences. Evolutionary biology explains homologous structures as retained her ...
, 'symmetry'.
See also
*
RB-64
RB-64 is a semi-synthetic derivative of salvinorin A. It is an irreversible agonist, with a reactive thiocyanate group that forms a bond to the κ-opioid receptor (KOR), resulting in very high potency. It is functionally selective, activating ...
References
{{Opioidergics
Synthetic opioids
Dissociative drugs
3-Furyl compounds
Lactones
Ethers
Cyclic ketones
Kappa-opioid receptor agonists
Methyl esters
Benzoisochromenes