CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase is an
enzyme that in humans is encoded by the ''ST8SIA4''
gene.
The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of
polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of
glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.
References
Further reading
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EC 2.4.99
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