Afadin- and alpha-actinin-binding protein is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''SSX2IP''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
It has been shown that it functions together with WDR8 in centrosome maturation, ensuring proper spindle length and orientation.
The SSX2IP-WDR8 complex additionally promotes ciliary vesicle docking during ciliogenesis.
Interactions
SSX2IP has been initially described as a protein to
interact
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with
MLLT4
Afadin is a protein that in humans is encoded by the ''AFDN'' gene.
Function
Afadin is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused ...
and
Actinin, alpha 1.
[ In the context of centrosome maturation and ciliogenesis it has been shown to interact with WDR8.]
References
Further reading
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