SSEM can refer to:
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Manchester Baby
The Manchester Baby, also called the Small-Scale Experimental Machine (SSEM), was the first electronic stored-program computer. It was built at the University of Manchester by Frederic Calland Williams, Frederic C. Williams, Tom Kilburn, and Ge ...
or Small-Scale Experimental Machine, historic computer
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South Seas Evangelical Mission, missionary organization in the Solomon Islands
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Serial-section electron microscopy (ssEM), a form of transmission electron microscopy
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Abreviación de la Secretaria de Seguridad del Estado de México S.S.E.M. (Policía del Estado de México) anteriormente Comisión Estatal de Seguridad Ciudadana (CES) y que se le modifico el nombre al tomar posesión de la gobernatura el Lic. Alfredo del Mazo 2017.