Sprouty-related,
EVH1 domain
WH1 domain is an evolutionary conserved protein domain. Therefore, it has an important function.
Function
WH1 domains are found on WASP proteins, which are often involved in actin polymerization. Hence, WH1 is important for all cellular process ...
-containing protein 2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''SPRED2''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
SPRED2 is a member of the Sprouty (see
SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see
MAPK1
Mitogen-activated protein kinase 1, (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the ''MAPK1'' gene.
Function
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extrace ...
).
References
Further reading
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External links
GeneReviews/NIH/NCBI/UW entry on Legius syndrome SPRED1 Sprouty-related, EVH1 domain-containing protein 1
SPR domain
EVH1 domain
Human proteins
{{gene-2-stub