E3 ubiquitin-protein ligase SMURF2 is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''SMURF2''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
which is located at chromosome 17q23.3-q24.1.
Interactions
SMURF2 has been shown to
interact with:
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Mothers against decapentaplegic homolog 1,
[
* ]Mothers against decapentaplegic homolog 2
Mothers against decapentaplegic homolog 2, also known as SMAD family member 2 or SMAD2, is a protein that in humans is encoded by the ''SMAD2'' gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the ''Dr ...
,[
* Mothers against decapentaplegic homolog 3,][
* SMURF1,]TOP2A
DNA topoisomerase IIα is a human enzyme encoded by the ''TOP2A'' gene.
Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining o ...
,
References
Further reading
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