SLU-PP-332 is a compound which is a potent but non-selective estrogen-related receptor (ERR)

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

, acting most strongly at ERRα with an EC₅₀ of 98 nM. It was found to counteract

metabolic syndrome Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). Metabolic syndro ...

in mice, suggesting a possible role for compounds from this class as medications for the treatment of obesity.

References

{{Estrogen-related receptor modulators 4-Hydroxyphenyl compounds Benzamides Naphthalenes Hydrazides Exercise mimetics Estrogen-related receptor modulators