Solute carrier organic anion transporter family member 2A1, also known as the prostaglandin transporter (PGT), is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the SLCO2A1
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning
organic anion-transporting polypeptide
Members of the Organic Anion Transporter (OAT) Family (organic-anion-transporting polypeptides, OATP) are membrane transport proteins or 'transporters' that mediate the transport of mainly organic anions across the cell membrane. Therefore, OATPs ...
superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of
prostaglandin
Prostaglandins (PG) are a group of physiology, physiologically active lipid compounds called eicosanoids that have diverse hormone-like effects in animals. Prostaglandins have been found in almost every Tissue (biology), tissue in humans and ot ...
s in numerous tissues.
Clinical relevance
Mutations in this gene have been shown to cause primary
hypertrophic osteoarthropathy
Hypertrophy is the increase in the volume of an organ or tissue due to the enlargement of its component Cell (biology), cells. It is distinguished from hyperplasia, in which the cells remain approximately the same size but increase in number. Al ...
,
.
References
Further reading
*
*
*
*
*
*
*
*
*
*
External links
*
Solute carrier family
{{gene-3-stub