Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''SLCO1B3''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the
portal vein
The portal vein or hepatic portal vein (HPV) is a blood vessel that carries blood from the gastrointestinal tract, gallbladder, pancreas and spleen to the liver. This blood contains nutrients and toxins extracted from digested contents. Approxima ...
.
Clinical significance
OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.
Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.
In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.
Substrates
Small molecules that are transported by SLCO1B3 include:
*
Amanitin
*
Atrasentan
*
Bilirubin
Bilirubin (BR) (adopted from German, originally bili—bile—plus ruber—red—from Latin) is a red-orange compound that occurs in the normcomponent of the straw-yellow color in urine. Another breakdown product, stercobilin, causes the brown ...
*
Bosentan
*
BQ-123
*
Bromsulphthalein (BSP)
* CDCA-NBD
*
Cholate (CA)
*
Cholecystokinin octapeptide (CCK-8)
* Dehydroepiandroserone-3-sulfate (
DHEAS)
* Deltorphin II
*
Demethylphalloin
*
Digoxin
Digoxin (better known as digitalis), sold under the brand name Lanoxin among others, is a medication used to treat various heart disease, heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. ...
*
Docetaxel
Docetaxel (DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small-cel ...
*
-penicillamine2,5nkephalin (DPDPE)
*
Enalapril
Enalapril, sold under the brand name Vasotec among others, is an ACE inhibitor medication used to treat high blood pressure, diabetic kidney disease, and heart failure. For heart failure, it is generally used with a diuretic, such as furosem ...
* Estradiol-17β-glucuronide 5–25
*
Estrone-3-sulfate
*
Fexofenadine
*
Fluvastatin
* Fluo-3
*
Glutathione (GSH)
*
Glycocholate (GCA)
*
Glycoursodeoxycholate (GUDCA)
*
Irinotecan
*
Leukotriene C4 (LTC4)
*
Methotrexate
Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immunosuppressive drug, immune-system suppressant. It is used to treat cancer, autoimmune diseases, and ectopic pregnancy, ectopic pregnancies. Types of cancers it is u ...
*
Microcystin
* Monoglyucuronosyl
*
Olmesartan
*
Ouabain
*
Paclitaxel
*
Phalloidin
*
Pitavastatin
*
Rifampicin
* Ro 48-5033 (
Bosentan metabolite)
*
Rosuvastatin
*
SN-38
*
Taurocholate (TCA)
*
Taurochenodeoxycholate (TCDCA)
*
Taurodeoxycholate (TDCA)
*
Tauroursodeoxycholate (TUDCA)
*
Telmisartan
*
Thyroxine
Thyroxine, also known as T4, is a hormone produced by the thyroid gland. It is the primary form of thyroid hormone found in the blood and acts as a prohormone of the more active thyroid hormone, triiodothyronine (T3). Thyroxine and its acti ...
(T4)
*
TR-14035
*
Triiodothyronine
Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.
Production of T3 and its prohormone thyroxi ...
(T3)
*
Valsartan
See also
*
Solute carrier family
The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 66 families. Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO ...
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Solute carrier family
Thyroid hormone transporters
{{membrane-protein-stub