S-phase kinase-associated protein 1 is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''SKP1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
This gene encodes a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that is a member of the
SCF ubiquitin ligase
A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin ...
protein complex
A protein complex or multiprotein complex is a group of two or more associated polypeptide chains. Protein complexes are distinct from multidomain enzymes, in which multiple active site, catalytic domains are found in a single polypeptide chain.
...
. It binds to
F-box proteins
F-box proteins are proteins containing at least one F-box domain. The first identified F-box protein is one of three components of the SCF complex, which mediates ubiquitination of proteins targeted for degradation by the 26S proteasome.
Core co ...
(proteins containing an F-box motif), such as cyclin F,
S-phase kinase-associated protein 2, and other regulatory proteins involved in
ubiquitin
Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ''ubiquitously''. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the late 1970s and 19 ...
dependent proteolysis.
The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor.
Alternative splicing
Alternative splicing, alternative RNA splicing, or differential splicing, is an alternative RNA splicing, splicing process during gene expression that allows a single gene to produce different splice variants. For example, some exons of a gene ma ...
of this gene results in two transcript variants. A related
pseudogene
Pseudogenes are nonfunctional segments of DNA that resemble functional genes. Pseudogenes can be formed from both protein-coding genes and non-coding genes. In the case of protein-coding genes, most pseudogenes arise as superfluous copies of fun ...
has been identified on chromosome 7.
Interactions
SKP1A has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with:
*
BTRC,
CACYBP
Calcyclin-binding protein is a protein that in humans is encoded by the ''CACYBP'' gene.
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradatio ...
,CDCA3
Cell division cycle-associated protein 3 is a protein that in humans is encoded by the ''CDCA3'' gene.
Interactions
CDCA3 has been shown to interact with SKP1A
S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by th ...
,CDK9
Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb.
Function
The protein encoded by this gene is a member of the cyclin-dependent kinase (CDK) family. CDK family members are highly similar to the gene produ ...
,CUL1
Cullin 1, also known as CUL1, is a human protein and gene from cullin family.
This protein plays an important role in protein degradation and protein ubiquitination.
This is an essential component of the SCF ( SKP1-CUL1- F-box protein) E3 ubi ...
,FBXL3
''FBXL3'' is a gene in humans and mice that encodes the F-box/LRR-repeat protein 3 (FBXL3).
FBXL3 is a member of the F-box protein family, which constitutes one of the four subunits in the SCF ubiquitin ligase complex.
The FBXL3 protein partici ...
,FBXO4
F-box only protein 4 is a protein that in humans is encoded by the ''FBXO4'' gene.
Function
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins c ...
,FBXO5
F-box only protein 5 is a protein that in humans is encoded by the ''FBXO5'' gene.
Function
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins c ...
,[
* ]FBXO7
F-box only protein 7 is a protein that in humans is encoded by the ''FBXO7'' gene. Mutations in FBXO7 have been associated with Parkinson's disease.
Function
This gene encodes a member of the F-box protein family which is characterized by an ...
,[
* ]FBXW2
F-box/WD repeat-containing protein 2 is a protein that in humans is encoded by the ''FBXW2'' gene.
Function
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F ...
,[
* ]FBXW7
F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the ''FBXW7'' gene.
Function
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The ...
,SKP2
S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the ''SKP2'' gene.
Structure and function
Skp2 contains 424 residues in total with the ~40 amino acid F-box domain lying closer to the N-terminal region at the 94-1 ...
.
References
Further reading
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External links
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{{PDB Gallery, geneid=6500