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SKF-89976A is an
Ex 1: Finkelstein Sn2 alkylation between 1,1-Diphenyl-4-bromobutene 078-95-1(1) & Ethyl nipecotate 006-62-2(2) gives 9203-62-3(3). Optional saponification of the ester group gives the title amino-acid compound (4).
Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1
Anticonvulsants GABA reuptake inhibitors Piperidines Carboxylic acids {{anticonvulsant-stub
anticonvulsant
Anticonvulsants (also known as antiepileptic drugs, antiseizure drugs, or anti-seizure medications (ASM)) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also used in the treatme ...
, acting as a GABA reuptake inhibitor
A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to incr ...
via blockade of GAT-1.Synthesis
Ex 1: Finkelstein Sn2 alkylation between 1,1-Diphenyl-4-bromobutene 078-95-1(1) & Ethyl nipecotate 006-62-2(2) gives 9203-62-3(3). Optional saponification of the ester group gives the title amino-acid compound (4).See also
References
External links
Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1
Anticonvulsants GABA reuptake inhibitors Piperidines Carboxylic acids {{anticonvulsant-stub