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Paired amphipathic helix protein Sin3a is a
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''SIN3A''
gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.


Function

The
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.


Interactions

SIN3A has been shown to interact with: * CABIN1 * HBP1, * HDAC1, * HDAC9, * Histone deacetylase 2, * Host cell factor C1, * IKZF1, * ING1, * KLF11, *
MNT MNT may stand for: */mnt in Unix, directory including mount points * Medical nutrition therapy * MNT (gene), a transcription factor * Molecular nanotechnology * Mongolian tögrög, the currency of Mongolia by ISO 4217 currency code *Mononitrotoluen ...
, * MXD1, * Methyl-CpG-binding domain protein 2, * Nuclear receptor co-repressor 2, * OGT, *
PHF12 PHD finger protein 12 is a protein that in humans is encoded by the ''PHF12'' gene. Interactions PHF12 has been shown to interact with SIN3A Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the ''SIN3A'' gene. ...
, * Promyelocytic leukemia protein, * RBBP4, * RBBP7, * SAP130, * SAP30, * SMARCA2, * SMARCA4, * SMARCC1, * SUDS3, *
TAL1 __NOTOC__ T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 .e. SCL/TAL1 is a protein that in humans is encoded by the ''TAL1'' gene. The protein encoded by TAL1 is a basic helix-l ...
, and * Zinc finger and BTB domain-containing protein 16.


See also

* Transcription coregulator


References


Further reading

* * * * * * * * * * * * * * * * * *


External links

* * {{NLM content Gene expression Transcription coregulators