SH3GLB1 on:
[Wikipedia]
[Google]
[Amazon]
Endophilin-B1 is a protein that in humans is encoded by the ''SH3GLB1'' gene. Endophilin-B1 belongs to the Bin/Amphiphysin/Rvs167 ( BAR) family of proteins and plays a critical role in
In the presence of model biological membranes, endophilin-B1 dimers assemble into helical scaffolds around the membrane and drive its tubulation.
mitochondrial fission
Mitochondrial fission is the process where mitochondria divide or segregate into two separate mitochondrial organelles. Mitochondrial fission is counteracted by the process of mitochondrial fusion, whereby two separate mitochondria can fuse togeth ...
and fusion, as well as in autophagy
Autophagy (or autophagocytosis; from the Ancient Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent re ...
and apoptosis
Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes incl ...
. Loss of functional endophilin-B1 is seen in many different forms of cancer. The link between carcinogenesis and dysregulation of cell death pathways suggests that endophilin-B1 serves a critical tumor suppressor role in the cell, although the underlying mechanisms are not known.
Structure
In the presence of model biological membranes, endophilin-B1 dimers assemble into helical scaffolds around the membrane and drive its tubulation.
Interactions
In addition to the membrane binding and remodeling properties endophilin-B1 shares with many other BAR proteins, endophilin-B1 interacts with the pro-apoptotic factor Bcl-2-associated X protein (Bax) andSH3GLB2
Endophilin-B2 is a protein that in humans is encoded by the ''SH3GLB2'' gene.
Interactions
SH3GLB2 has been shown to interact with SH3GLB1
Endophilin-B1 is a protein that in humans is encoded by the ''SH3GLB1'' gene. Endophilin-B1 belongs ...
. It has also been shown to interact with a wide variety of proteins through a canonical SH3 domain that enables PxxP motif-containing protein interactions, including Beclin-1
Beclin-1 is a protein that in humans is encoded by the ''BECN1'' gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k cla ...
, amphiphysin-1, amphiphysin-2, and huntingtin.
References
Further reading
* * * * * * * * * * * * {{gene-1-stub