Serine/threonine-protein kinase Sgk2 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''SGK2''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
This gene encodes a
serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (
SGK
Serine/threonine-protein kinases SGK represent a kinase subfamily with orthologs found across animal clades and in yeast (comparTreefam family TF320906. In most vertebrates, including humans, there are three isoforms encoded by the genes ''SGK1' ...
), this gene is not induced by
serum or
glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase (
PI3K), which is also true for SGK. Two
alternate transcripts encoding two different
isoforms
A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences. While many perform the same or similar biological roles, some isof ...
have been described.
References
Further reading
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External links
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EC 2.7.11
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