Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a
protein that in humans is encoded by the ''SRSF7''
gene.
Function
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-
mRNA splicing factors, which constitute part of the
spliceosome. Each of these factors contains an
RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in
serine
Serine (symbol Ser or S) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated − form under biological conditions), a carboxyl group (which is in the deprotonated − form un ...
and
arginine
Arginine is the amino acid with the formula (H2N)(HN)CN(H)(CH2)3CH(NH2)CO2H. The molecule features a guanidino group appended to a standard amino acid framework. At physiological pH, the carboxylic acid is deprotonated (−CO2−) and both the am ...
residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.
Model organisms
Model organism
A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workin ...
s have been used in the study of SRSF7 function. A conditional
knockout mouse line called ''Srsf7
tm1a(EUCOMM)Wtsi'' was generated at the
Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized
phenotypic screen to determine the effects of deletion.
Additional screens performed: - In-depth immunological phenotyping
References
Further reading
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