Splicing factor, arginine/serine-rich 2 is a
protein that in humans is encoded by the ''SFRS2''
gene.
MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis.
Interactions
SFRS2 has been shown to
interact with
CDC5L and
ASF/SF2.
References
Further reading
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External links
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{{gene-17-stub