Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
encoded by the ''SFN''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
in humans.
The protein is named for its presence in stratified
epithelial cells
Epithelium or epithelial tissue is a thin, continuous, protective layer of cells with little extracellular matrix. An example is the epidermis, the outermost layer of the skin. Epithelial ( mesothelial) tissues line the outer surfaces of man ...
.
Interactions
Stratifin has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
PLK4
Serine/threonine-protein kinase PLK4 also known as polo-like kinase 4 is an enzyme that in humans is encoded by the ''PLK4'' gene. The ''Drosophila'' homolog is SAK, the ''C. elegans'' homolog is zyg-1, and the ''Xenopus'' homolog is Plx4.
Func ...
,
ERRFI1
ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ''ERRFI1'' gene.
MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein ...
,
MARK3
MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the ''MARK3'' gene.
Interactions
MARK3 has been shown to interact with Stratifin
Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is ...
,
[ JUB][ and ]YWHAG
14-3-3 protein gamma is a protein that in humans is encoded by the ''YWHAG'' gene.
This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved p ...
.[
]
References
Further reading
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{{gene-1-stub
14-3-3 proteins