Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''SF1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Splicing factor SF1 is involved in the ATP-dependent formation of the
spliceosome complex.
SF1 gene is necessary to make the bipotential gonad; but while SF1 levels decline in the genital ridge of XX mouse embryos, the SF1 gene stays on the developing testes. SF 1 (transcription factor) appears to be active in masculining both the Leydig cells and Sertoli cells. In Sertoli cells with the SOX9 protein it elevates the level of AMH transcription. In Leydig cells it activates the gene encoding the enzyme that make testosterone hormone.
Interactions
SF1 (gene) has been shown to
interact with
Ewing sarcoma breakpoint region 1,
,
,
and
transcription elongation regulator 1.
References
Further reading
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