SCHEMBL19952957 is an
oxadiazole Oxadiazoles are a class of heterocyclic aromatic chemical compounds of the azole family with the molecular formula . There are four isomers of oxadiazole:
File:1,2,3-oxadiazole.svg, 1,2,3-oxadiazole
File:1,2,4-oxadiazole.svg, 1,2,4-oxadiazole
File ...
based
antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...
, originally developed in 2014 as a potential treatment for infections with
methicillin-resistant ''Staphylococcus aureus'' (MRSA) and other antibiotic-resistant bacteria. Subsequently, it has been found to be useful against ''
Clostridioides difficile
''Clostridioides difficile'' ( syn. ''Clostridium difficile'') is a bacterium known for causing serious diarrheal infections, and may also cause colon cancer. It is known also as ''C. difficile'', or ''C. diff'' (), and is a Gram-positive spec ...
'' as it not only kills active bacteria but also inhibits the germination of the dormant spores which can otherwise often lead to persistent infections that repeatedly recur upon cessation of antibiotic treatment. While it is still only being researched in animals at this stage, this dual action is a significant advance over existing antibiotics, and it is likely that drugs from this class may be developed as new medications for the treatment of antibiotic-resistant infections in humans.
See also
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Cadazolid
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Fidaxomicin
Fidaxomicin, sold under the brand name Dificid (by Merck) among others, is the first member of a class of narrow spectrum macrocyclic antibiotic drugs called tiacumicins. It is a fermentation product obtained from the actinomycete '' Dactylosp ...
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Ridinilazole
Ridinilazole (previously known as SMT19969) is an investigational small molecule antibiotic under evaluation for oral administration for the treatment of Clostridioides difficile infection, ''Clostridioides difficile'' infection (CDI). In vitro, ...
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Surotomycin
Surotomycin was an investigational oral antibiotic. This macrolide antibiotic was under investigation by Merck & Co (who acquired Cubist Pharmaceuticals) for the treatment of life-threatening diarrhea, commonly caused by the bacterium ''Clostridi ...
References
{{antibiotic-stub
Oxadiazoles
4-Hydroxyphenyl compounds
Cyclopentanols
Aromatic ethers