Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a

coronavirus Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the comm ...

related to '' Rhinolophus bat coronavirus HKU2''. It is transmitted through the feces of

horseshoe bat Horseshoe bats are bats in the family Rhinolophidae. In addition to the single living genus, ''Rhinolophus'', which has about 106 species, the extinct genus '' Palaeonycteris'' has been recognized. Horseshoe bats are closely related to the Ol ...

s to

pig The pig (''Sus domesticus''), also called swine (: swine) or hog, is an omnivorous, domesticated, even-toed, hoofed mammal. It is named the domestic pig when distinguishing it from other members of the genus '' Sus''. Some authorities cons ...

s. Piglets less than 5 days old die with a probability of up to 90%. The first outbreak appeared in 2017, where it caused the death of more than 24,000 piglets on 4 farms. In 2018 and 2019, the virus re-emerged in China, but there were not large-scale losses. This weak re-emergence is curious, and is reminiscent of how SARS emerged in 2003 and then disappeared. During ''

in vitro ''In vitro'' (meaning ''in glass'', or ''in the glass'') Research, studies are performed with Cell (biology), cells or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in ...

'' testing, human and monkey cell lines exposed to SADS-CoV became infected, suggesting that SADS-CoV may pose a risk to human health. The SADS-CoV sampled from one of the first infected pig farms was found to be 95% genetically identical to one collected from horseshoe bats (''Rhinolophus''), "indicating the bat origin of the pig virus".

References

{{Taxonbar, from=Q55643348 Alphacoronaviruses Unaccepted virus taxa