Srinivasa Murty Srinivasula is an Indian

cell biologist Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living an ...

, a professor at the School of Biology at the

Indian Institute of Science Education and Research, Thiruvananthapuram Indian Institute of Science Education and Research, Vithura, Thiruvananthapuram (IISER Thiruvananthapuram or IISER-TVM) is an autonomous public university located in Vithura, Kerala, India. The institute is one of the seven Indian Institutes of S ...

(IISER Thiruvananthapuram) in

Kerala Kerala ( , ) is a States and union territories of India, state on the Malabar Coast of India. It was formed on 1 November 1956, following the passage of the States Reorganisation Act, by combining Malayalam-speaking regions of the erstwhile ...

India India, officially the Republic of India, is a country in South Asia. It is the List of countries and dependencies by area, seventh-largest country by area; the List of countries by population (United Nations), most populous country since ...

. His research field is

apoptosis Apoptosis (from ) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. Biochemistry, Biochemical events lead to characteristic cell changes (Morphology (biol ...

autophagy Autophagy (or autophagocytosis; from the Greek language, Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-depe ...

and

oncology Oncology is a branch of medicine that deals with the study, treatment, diagnosis, and prevention of cancer. A medical professional who practices oncology is an ''oncologist''. The name's Etymology, etymological origin is the Greek word ὄγ ...

Life and career

Professor Murty received his B.Sc and

M.Sc A Master of Science (; abbreviated MS, M.S., MSc, M.Sc., SM, S.M., ScM or Sc.M.) is a master's degree. In contrast to the Master of Arts degree, the Master of Science degree is typically granted for studies in sciences, engineering and medicine ...

degrees from the

Andhra University Andhra University is a public university located in Visakhapatnam, Andhra Pradesh, India. It was established in 1926. It is graded as an A++ institution by NAAC receiving a score of 3.74 on a scale of 4. History King Vikram Deo Verma, the Mah ...

and his

PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

from the

Banaras Hindu University Banaras Hindu University (BHU), formerly Benares Hindu University, is a collegiate, central, and research university located in Varanasi, Uttar Pradesh, India, and founded in 1916. The university incorporated the Central Hindu College, ...

Varanasi Varanasi (, also Benares, Banaras ) or Kashi, is a city on the Ganges river in northern India that has a central place in the traditions of pilgrimage, death, and mourning in the Hindu world.* * * * The city has a syncretic tradition of I ...

, India. He later moved to the

Thomas Jefferson University Thomas Jefferson University is a Private university, private research university in Philadelphia, Pennsylvania, United States. Established in its earliest form in 1824, the university officially combined with Philadelphia University in 2017. ...

as a research associate and became an instructor at the Sidney Kimmel Cancer Center at

Philadelphia Philadelphia ( ), colloquially referred to as Philly, is the List of municipalities in Pennsylvania, most populous city in the U.S. state of Pennsylvania and the List of United States cities by population, sixth-most populous city in the Unit ...

, United States. During 2003–2012, he was the principal investigator at National Cancer Institute, NIH, Bethesda. He was Professor-in-charge (administration) at the IISER Thiruvananthapuram, as well as the member of the IISER TVM Senate. He also served on several institute committees. Currently he is Deputy Director of the institute.

Key awards and distinctions

Professor Murty has received the following awards: * Kimmel Scholar (2003-2005), The

Sidney Kimmel Sidney J. Kimmel (born January 16, 1928) is an American businessman, philanthropist, and film producer. He is ranked 2141st in the ''Forbes'' list of the richest people alive in 2021. Personal life Kimmel was born into a Jewish family in Phi ...

Foundation for Cancer Research, Baltimore, MD * Special Fellow (2000-2003), The Leukemia and Lymphoma Society, New York, NY * Young Scientist Travel Award,

American Association for Cancer Research The American Association for Cancer Research (AACR) is the world's oldest and largest professional association related to cancer research. Based in Philadelphia, the AACR focuses on all aspects of cancer research, including Basic research, basic, ...

, Inc. Philadelphia * Research Fellowships (1987-1992),

University Grants Commission (India) University Grants Commission (UGC; ISO: ''Viś‍vavidyālaya Anudāna Āyōga'') is a statutory body under Department of Higher Education, Ministry of Education, Government of India. It was set up in accordance to the UGC Act 1956 and i ...

* National Merit Scholarships (1984 -1986), Department of Education, Government of India, New Delhi

Publications

Professor Murty has published around 100 papers and reviews in international

scientific journal In academic publishing, a scientific journal is a periodical publication designed to further the progress of science by disseminating new research findings to the scientific community. These journals serve as a platform for researchers, schola ...

Key publications

# Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D. (2012). PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα (12). Nat. Cell Biol # Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997). Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade. Cell, 91(4), 479–489. # Fujita K and Srinivasula SM. (2011). TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS). Autophagy, 7: 29–31. # Fujita K, Xiao Q, Maeda D and Srinivasula SM. (2011). Nrf2-mediated induction of p62 controls TLR4-driven ALIS formation and autophagic degradation, Proc Nat Acad Sci, USA, 108: 1427–32. # Shukla S, Fujita K, Xiao Q, and Srinivasula SM. (2011). A

shear stress Shear stress (often denoted by , Greek alphabet, Greek: tau) is the component of stress (physics), stress coplanar with a material cross section. It arises from the shear force, the component of force vector parallel to the material cross secti ...

responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface. Apoptosis, 16: 162–173. # Liao, W, Fujita K, Xiao Q, Tchikov V, Yang W, Gunsor, M, Garfield S, Goldsmith, P. El-Deiry WS, Schutze S, and Srinivasula SM. (2009). CARP1 Regulates Induction of NF-κB by TNF-a. Current Biology. 19: R17-R19 # Liao, W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S, Garfield S, Schutze S, El-Deiry WS, and Srinivasula SM. (2008). CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-?B activation. Current Biology (article). 18: 641–9. # Srinivasula SM, Jones JM., Datta P., Ji W., Gupta S., Zhang Z., Davies E., Hajnóczky G., Saunders TL., Van Keuren ML., Alnemri T., Meisler ML and Alnemri ES. (2003). Loss of Omi/HtrA2 protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature. 425: 721–727. # Srinivasula SM, Datta P, Kobayashi M, Wu J-W, Fujioka M, Hegde R, Zhang Z, Mukattash, Fernandes-Alnemri T, Shi Y, Jaynes JB, Alnemri ES. (2002). ''Sickle'', a novel Drosophila death gene in the reaper/hid/grim region encodes an IAP-inhibitory protein. Curr Biol. 12: 125–30. # Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA., Robbins PD, Fernandes-Alnemri T, Shi Y., Alnemri ES. (2001). A conserved XIAP-interaction motif in caspase-9 and Smac/Diablo regulates caspase activity and apoptosis. Nature. 410: 112–16. # Srinivasula SM, Saleh A, Balkir L, Robbins PD, and Alnemri ES. (2000). Negative regulation of the Apaf-1 apoptosome by Hsp70. Nature Cell Biol 2: 476–483.

Book chapters

# Fujita, K and Srinivasula SM. (2009). Ubiquitination and Death-receptor signaling. Death Receptors and Cognate Ligands in Cancer. Results Probl Cell Differ, SpringerLinks Publisher. 49: 87-114. # Srinivasula SM, Saleh A, Ahmad M, Fernandes-Alnemri T, Alnemri ES. (2001). Isolation and Assay of Caspases. Ch. 1. Methods in Cell Biol. 66:1-27.

External links

Profile page
at

IISER Thiruvananthapuram Indian Institute of Science Education and Research, Vithura, Thiruvananthapuram (IISER Thiruvananthapuram or IISER-TVM) is an autonomous public university located in Vithura, Kerala, India. The institute is one of the seven IISERs established by ...

Faculty profile
at IRINS

References

{{DEFAULTSORT:Srinivasula, S. Murty Living people Indian molecular biologists 20th-century Indian biologists 1963 births