Rudolf Aebersold (better known as Ruedi Aebersold; born September 12, 1954) is a Swiss biologist, regarded as a pioneer in the fields of

proteomics Proteomics is the large-scale study of proteins. Proteins are vital macromolecules of all living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replicatio ...

and

systems biology Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological system ...

. He has primarily researched techniques for measuring

proteins Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, re ...

in complex samples, in many cases via

mass spectrometry Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a ''mass spectrum'', a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is used ...

. Ruedi Aebersold is a professor of Systems biology at the Institute of Molecular Systems Biology (IMSB) in

ETH Zurich ETH Zurich (; ) is a public university in Zurich, Switzerland. Founded in 1854 with the stated mission to educate engineers and scientists, the university focuses primarily on science, technology, engineering, and mathematics. ETH Zurich ran ...

. He was one of the founders of the

Institute for Systems Biology Institute for Systems Biology (ISB) is a non-profit research institution located in Seattle, Washington, United States. ISB concentrates on systems biology, the study of relationships and interactions between various parts of biological systems, ...

in Seattle, Washington, United States where he previously had a research group. Aebersold is known for the development and application of targeted proteomics techniques in the field of biomedical research, in order to understand the function, interaction and localization of each protein in the cell and its changes in disease states. To this end, Ruedi Abersold has made significant contributions in the development and application of targeted proteomics methods, including

selected reaction monitoring Selected reaction monitoring (SRM), also called multiple reaction monitoring (MRM), is a method used in tandem mass spectrometry in which an ion of a particular mass is selected in the first stage of a tandem mass spectrometer and an ion product ...

and data-independent acquisition. Ruedi Aebersold is also recognized for its contributions in the development of standard formats and open source software for the analysis and storage of mass spectrometry and proteomics data, and he is one of the inventors of the

Isotope-Coded Affinity Tag An isotope-coded affinity tag (ICAT) is an ''in-vitro'' isotopic labeling method used for quantitative proteomics by mass spectrometry that uses chemical labeling reagents. These chemical probes consist of three elements: a reactive group for label ...

(ICAT) technique for quantitative proteomics, a technique that measures the relative quantities of proteins between two sample by using tags containing stable isotopes of different masses. Aebersold is co-founder and scientific advisor of the companies ProteoMediX and Biognosys.

Honors and awards

* 2005 – HUPO Award * 2006 – Buchner Medal * 2008 – In recognition of his contribution to the field of protein sciences and proteomics the

Association of Biomolecular Resource Facilities The Association of Biomolecular Resource Facilities (ABRF) is dedicated to advancing core and research biotechnology laboratories through research, communication, and education. ABRF members include over 2000 scientists representing 340 differe ...

(ABRF) selected him for the ABRF 2008 Award. * 2010 – Herbert A. Sober Lectureship * 2010 – Otto Naegeli Prize * 2012 – Thomson Medal Award *In 2014 he became a member of the

German Academy of Sciences Leopoldina The German National Academy of Sciences Leopoldina (), in short Leopoldina, is the national academy of Germany, and is located in Halle (Saale). Founded on 1 January 1652, based on academic models in Italy, it was originally named the ''Academi ...

. * 2015 – ranked #1 on the 2015 list of "most influential people in the analytical sciences" (by the Analytical Scientist) * 2018 – Bijvoet Medal of the

Bijvoet Center for Biomolecular Research The Bijvoet Centre for Biomolecular Research is a research institute at Utrecht University. The Bijvoet Centre performs Structural biology, research on the relation between the structure and function of biomolecules, including proteins and lipids, ...

Utrecht University Utrecht University (UU; , formerly ''Rijksuniversiteit Utrecht'') is a public university, public research university in Utrecht, Netherlands. Established , it is one of the oldest universities in the Netherlands. In 2023, it had an enrollment of ...

* 2020 –

Marcel Benoist Prize The Marcel Benoist Prize, offered by the Marcel Benoist Foundation, is a monetary prize that has been offered annually since 1920 to a scientist of Swiss nationality or residency who has made the most useful scientific discovery. Emphasis is pl ...

Marcel Benoist Prize 2020
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References

{{DEFAULTSORT:Aebersold, Ruedi 1954 births Living people Members of the European Molecular Biology Organization Swiss biologists Systems biologists Academic staff of ETH Zurich Mass spectrometrists Bijvoet Medal recipients Thomson Medal recipients Members of the German National Academy of Sciences Leopoldina