In genetics, rs28363170 (DAT1-VNTR) is a genetic variation at '' SLC6A3'', the gene that encodes the

dopamine transporter The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in humans by the ''SLC6A3'' gene (also known as ''DAT1''), that pumps the neurotransmitter dopamine out of the synaptic cleft ba ...

. It is polymorphism as a 40 base pairs

VNTR A variable number tandem repeat (or VNTR) is a location in a genome where a short nucleotide sequence is organized as a tandem repeat. These can be found on many chromosomes, and often show variations in length (number of repeats) among individ ...

in the 3' untranslated region. It is a

deletion/insertion polymorphism Indel (insertion-deletion) is a molecular biology term for an insertion or deletion of bases in the genome of an organism. Indels ≥ 50 bases in length are classified as structural variants. In coding regions of the genome, unless the length ...

(DIP). The 9-repeat and the 10-repeat are the most common alleles.

References

Further

* * {{Cite journal , doi = 10.1038/sj.npp.1301240 , year = 2007 , last2 = Grizenko , first2 = N , last3 = Sengupta , first3 = S , last4 = Amor , first4 = LB , last5 = Schmitz , first5 = N , last6 = Schwartz , first6 = G , last7 = Karama , first7 = S , last8 = Lageix , first8 = P , last9 = Fathalli , first9 = F , last10 = Torkaman-Zehi , first10 = Adam , last11 = Stepanian , first11 = Marina Ter , title = Dopamine transporter 3'-UTR VNTR genotype and ADHD: a pharmaco-behavioural genetic study with methylphenidate , journal = Neuropsychopharmacology , volume = 32 , issue = 6 , pages = 1370–1376 , pmid = 17063150 , display-authors = 8 , last1 = Joober , first1 = R. , s2cid = 2944059