Rosalind Ridley
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Rosalind Ridley is a British psychologist and researcher who was head of the
Medical Research Council (United Kingdom) The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together ...
Comparative Cognition Research Team in the Department of Psychology, Cambridge, UK, until 2005. She was a fellow of Newnham College, Cambridge from 1995–2010 and Vice-Principal from 2000–2005. She holds the privileges of a Fellow Emerita at Newnham College.


Education and career

Rosalind Mary Ridley was born in
Coventry Coventry ( or rarely ) is a City status in the United Kingdom, cathedral city and metropolitan borough in the West Midlands (county), West Midlands county, in England, on the River Sherbourne. Coventry had been a large settlement for centurie ...
, UK and educated at Barr's Hill Grammar School, Coventry and Newnham College,
Cambridge University The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...
(1968-71), where she read Natural Sciences (biological), majoring in Psychology. She obtained her PhD at the
Institute of Psychiatry The Institute of Psychiatry, Psychology & Neuroscience (IoPPN) is a centre for mental health and neuroscience research, education and training in Europe. It is dedicated to understanding, preventing and treating mental illness, neurological co ...
, London under the supervision of George Ettlinger. In 1977, she joined the Clinical Research Centre, Division of Psychiatry at Northwick Park Hospital,
Harrow, London Harrow () is a large town in Greater London, England, and serves as the principal settlement of the London Borough of Harrow. Lying about north-west of Charing Cross and south of Watford, the entire town including its localities had a populat ...
.


Research

Ridley's research career started with an investigation into cortical mechanisms of
visual perception Visual perception is the ability to detect light and use it to form an image of the surrounding Biophysical environment, environment. Photodetection without image formation is classified as ''light sensing''. In most vertebrates, visual percept ...
followed by the delineation of the cortical areas involved in somatosensory discrimination learning. Her early career involved work on the role of
dopamine Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. It is an amine synthesized ...
in cognitive perseveration and motor
stereotypy A stereotypy (, ) is a repetitive or ritualistic movement, posture, or utterance. Stereotypies may be simple movements such as body rocking, or complex, such as self-caressing, crossing and uncrossing of legs, and marching in place. They are foun ...
, but her interests then extended to the role of the
hippocampus The hippocampus (: hippocampi; via Latin from Ancient Greek, Greek , 'seahorse'), also hippocampus proper, is a major component of the brain of humans and many other vertebrates. In the human brain the hippocampus, the dentate gyrus, and the ...
in simple and conditional learning. Much of her research effort was directed towards developing treatments for
Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems wit ...
,
Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become ...
and
Huntington's disease Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease that is mostly Genetic disorder#Autosomal dominant, inherited. It typically presents as a triad of progressive psychiatric, cognitive, and ...
. She and her research collaborators demonstrated that
acetylcholine Acetylcholine (ACh) is an organic compound that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Par ...
was crucial for various types of
memory Memory is the faculty of the mind by which data or information is encoded, stored, and retrieved when needed. It is the retention of information over time for the purpose of influencing future action. If past events could not be remembe ...
formation and established that transplantation of neural tissue into the brain could restore memory and learning ability. She also maintained an interest in the genetics of neurodegenerative diseases. Ridley was involved in early work on transmissible spongiform encephalopathy (subsequently known as prion disease), particularly in the recognition that individual cases of human prion disease could be sporadic, familial or acquired and that familial cases were associated with mutations in the prion protein gene. She demonstrated the transmissibility of bovine spongiform encephalopathy (BSE) and scrapie to primates and argued that the evidence for BSE and scrapie being acquired by maternal transmission was also compatible with genetic susceptibility to disease. In experiments using data extending over 25 years, she demonstrated that the
amyloid Amyloids are aggregates of proteins characterised by a fibrillar morphology of typically 7–13 nm in diameter, a β-sheet secondary structure (known as cross-β) and ability to be stained by particular dyes, such as Congo red. In the human ...
proteins found in Alzheimer's disease were self-assembling and experimentally transmissible, establishing a link in pathogenesis between prion diseases and the other neurodegenerative proteinopathies Ridley's current research lies in aspects of cognitive psychology to be found in late nineteenth and early twentieth century books for children, especially the works of J. M. Barrie.


Personal life

In 1981, Ridley married her colleague Harry Baker. She is a member of the Cambridge Drawing Society and the Cambridge District Art Circle


Select bibliography

* ''Fatal Protein. The story of CJD, BSE and other prion diseases'' (1998) Ridley, R. M. and Baker, H. F. Oxford University Press. * ''Prion Diseases'' (1996) Baker, H. F. and Ridley, R. M. Eds. Humana Press Inc., Totowa, New Jersey. * ''Peter Pan and the Mind of J. M. Barrie. An Exploration of Cognition and Consciousness'' (2016) Ridley, R. M. Cambridge Scholars Publishing. ''''


References


External links

*
Website: https://sites.google.com/view/rosalindridley/home
{{DEFAULTSORT:Ridley, Rosalind 1949 births Living people Alumni of Newnham College, Cambridge British women psychologists