Roland Mertelsmann is a hematologist, oncologist and professor emeritus at the

University Medical Center Freiburg The University Medical Center Freiburg ''(Universitätsklinikum Freiburg)'' in Freiburg, Germany is the teaching hospital and part of the medical research unit of the University of Freiburg and home to its Faculty of Medicine. The medical center i ...

, Department of Oncology, Hematology and Stem Cell Transplantation in

Freiburg im Breisgau Freiburg im Breisgau or simply Freiburg is the List of cities in Baden-Württemberg by population, fourth-largest city of the German state of Baden-Württemberg after Stuttgart, Mannheim and Karlsruhe. Its built-up area has a population of abou ...

, Germany. Mertelsmann is known for his scientific works in the fields of hematology, oncology,

gene therapy Gene therapy is Health technology, medical technology that aims to produce a therapeutic effect through the manipulation of gene expression or through altering the biological properties of living cells. The first attempt at modifying human DNA ...

and

stem cell transplantation Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce a ...

Biography

Mertelsmann studied medicine at the

University of Göttingen The University of Göttingen, officially the Georg August University of Göttingen (, commonly referred to as Georgia Augusta), is a Public university, public research university in the city of Göttingen, Lower Saxony, Germany. Founded in 1734 ...

1966–68. He was a doctoral candidate at the Max Planck Institute for Experimental Medicine at Heinrich Matthaei in Göttingen 1966–68. He continued his medical education at the School of Medicine King's College London and at the

Columbia-Presbyterian Medical Center Columbia University Irving Medical Center (CUIMC) is the academic medical center of Columbia University and the largest campus of NewYork-Presbyterian Hospital. The center's academic wing consists of Columbia's colleges and schools of Physician ...

, New York 1968–78. After graduating from Hamburg University Medical School and receiving his MD degree, he became Research Fellow at the Department of Developmental Hematopoiesis and received a special fellowship in Hematology and Clinical Oncology at

Memorial Sloan-Kettering Cancer Center Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a oncology, cancer treatment and research institution in Manhattan in New York City. MSKCC is one of 72 National Cancer Institute–NCI-designated Cancer Center, designated Comprehen ...

(MSKCC), 1976–78. There he contributed to the isolation of the blood stimulating growth factor

G-CSF Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Function ...

, which leads to a faster recovery of white blood cells after

chemotherapy Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (list of chemotherapeutic agents, chemotherapeutic agents or alkylating agents) in a standard chemotherapy re ...

and

radiation therapy Radiation therapy or radiotherapy (RT, RTx, or XRT) is a therapy, treatment using ionizing radiation, generally provided as part of treatment of cancer, cancer therapy to either kill or control the growth of malignancy, malignant cell (biology), ...

protecting patients better against severe infections. From 1978 to 86 he was clinical assistant physician at MSKCC, then assistant attending physician and associate attending physician at the Memorial Hospital of Sloan-Kettering Cancer Center. He was promoted from assistant professor of medicine to associate professor of medicine at

Cornell University Cornell University is a Private university, private Ivy League research university based in Ithaca, New York, United States. The university was co-founded by American philanthropist Ezra Cornell and historian and educator Andrew Dickson W ...

, New York. In 1985, he returned to Germany and was appointed professor and head of the 3rd Medical Clinic Hematology and Oncology at the University of Mainz, Germany, University Medical Center. 1989 he accepted a professorship at the

University of Freiburg The University of Freiburg (colloquially ), officially the Albert Ludwig University of Freiburg (), is a public university, public research university located in Freiburg im Breisgau, Baden-Württemberg, Germany. The university was founded in 1 ...

. At Freiburg University Medical Center he became the director of the Department for Medicine I, Oncology, Hematology and Stem Cell Transplantation. He retired in 2012. In 2008 he founded the International Master/PhD Program in Biomedical Sciences (IMBS), a postgraduate initiative jointly run by the

University of Buenos Aires The University of Buenos Aires (, UBA) is a public university, public research university in Buenos Aires, Argentina. It is the second-oldest university in the country, and the largest university of the country by enrollment. Established in 1821 ...

in Argentina and the University of Freiburg in Germany. In 2014 he initiated the foundation of the Journal of Science, Humanities and Arts (JOSHA), a

diamond open access Diamond open access refers to academic texts (such as monographs, edited collections, and journal articles) published/distributed/preserved with no fees to either reader or author. Alternative labels include platinum open access, non-commercial o ...

interdisciplinary journal. Mertelsmann published more than 400 articles in medical journals.

Scientific contribution

Molecular and cellular mechanisms of malignancy- First description of a human RNA polymerase

After discovery of the genetic code by Heinrich Matthaei and

Marshall Nirenberg Marshall Warren Nirenberg (April 10, 1927 – January 15, 2010) was an American biochemist and geneticist. He shared a Nobel Prize in Physiology or Medicine in 1968 with Har Gobind Khorana and Robert W. Holley for "breaking the genetic code" a ...

(1962), Mertelsmann began his research for his medical doctorate as a medical student in Heinrich Matthaei's Laboratory at the Max-Planck-Institute for experimental Medicine in Göttingen, Germany, demonstrating and characterizing for the first time a human RNA-Polymerase.R. Mertelsmann: ''Purification and some properties of a soluble DNA-dependent. RNA polymerase from nuclei of human placenta.'' In: ''Eur. J. Biochem.'' 1969 Jun;9(3), S. 311–318. Since nucleic acid synthesis is an important target for chemotherapeutic agents, he subsequently investigated in his team together with various colleagues, DNA-Polymerases, especially

terminal deoxynucleotidyl transferase Terminal deoxynucleotidyl transferase (TdT), also known as DNA nucleotidylexotransferase (DNTT) or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphom ...

(TdT), and RNA-Polymerases as diagnostic and prognostic markers in

leukemia Leukemia ( also spelled leukaemia; pronounced ) is a group of blood cancers that usually begin in the bone marrow and produce high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or '' ...

s and

lymphoma Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). The name typically refers to just the cancerous versions rather than all such tumours. Signs and symptoms may include enlarged lymph node ...

s.R. Mertelsmann, B. Koziner, D. A. Filippa, E. Grossbard, G. Incefy, M. A. Moore, B. D. Clarkson: ''Clinical significance of TdT, cell surface markers and CFU-C in 297 patients with hematopoietic neoplasias.'' In: ''Haematol Blood Transfus.'' 1979;23, S. 131–138. . Prof. em. Dr. Drs. h.c. Roland Mertelsmann

Studies of the Pathophysiology and Molecular Biology of Cancer Cells

The "Plasticity" of

hematopoietic Haematopoiesis (; ; also hematopoiesis in American English, sometimes h(a)emopoiesis) is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells. In a healthy adult human, roughly ten ...

stem cells In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell ...

(HSC), i.e. the differentiation of HSC into cells of other organs,R. Mertelsmann: ''Plasticity of bone marrow-derived stem cells.'' In: ''J Hematother Stem Cell Res.'' 2000 Dec;9(6), S. 957–960. Review. was intensively studied with Alexandros SpyridonidisA. Spyridonidis, R. Mertelsmann, J. Finke: ''Hematopoietic stem cell transplantation: more than just hematopoietic?'' In: ''J Cancer Res Clin Oncol.'' 2004 Mar;130(3), S. 127–134. Epub 2004 Jan 16. Review. in patients after allogeneic

bone marrow transplantation Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce a ...

. These studies demonstrated conclusively, that this phenomenon can be observed in these patients, but is a rare event. Molecular mechanisms of

B-cell B cells, also known as B lymphocytes, are a type of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system. B cells produce antibody molecules which may be either secreted or inserted into the plasm ...

neoplasia A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...

sM. Binder, F. Müller, M. Frick, C. Wehr, F. Simon, B. Leistler, H. Veelken, R. Mertelsmann, M. Trepel: ''CLL B-cell receptors can recognize themselves: alternative epitopes and structural clues for autostimulatory mechanisms in CLL.'' In: ''Blood.'' 2013 Jan 3;121(1), S. 239–241. doi:10.1182/blood-2012-09-454439. C. Dierks, J. Grbic, K. Zirlik, R. Beigi, N. P. Englund, G. R. Guo, H. Veelken, M. Engelhardt, R. Mertelsmann, J. F. Kelleher, P. Schultz, M. Warmuth: ''Essential role of stromally induced hedgehog signaling in B-cell malignancies.'' In: ''Nat Med.'' 2007 Aug;13(8), S. 944–951. Epub 2007 Jul 15. . were investigated together with Binder, Trepel and Dierks, the pathogenic significance of granulocytes in

Graft-versus-host disease Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. GvHD is commonly associated with bone marrow transplants and stem cell transplants. White blood cells of the donor's immune system which rema ...

with Zeiser and his colleagues.L. Schwab, L. Goroncy, S. Palaniyandi, S. Gautam, A. Triantafyllopoulou, A. Mocsai, W. Reichardt, F. J. Karlsson, S. V. Radhakrishnan, K. Hanke, A. Schmitt-Graeff, M. Freudenberg, F. D. von Loewenich, P. Wolf, F. Leonhardt, N. Baxan, D. Pfeifer, O. Schmah, A. Schönle, S. F. Martin, R. Mertelsmann, J. Duyster, J. Finke, M. Prinz, P. Henneke, H. Häcker, G. C. Hildebrandt, G. Häcker, R. Zeiser: ''Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage.'' In: ''Nat Med.'' 2014 Jun;20(6), S. 648–654. doi:10.1038/nm.3517. Epub 2014 May 18.

Clinical Significance of the Leukemia Phenotype

As a member of the clinical (Director Bayard Clarkson) and laboratory teams (Director Malcolm A.S. Moore), he carried out a systematic analysis of all patients with acute myeloid leukemia (AML) treated at MSKCC, defining the prognostic and predictive parameters of cell

cytology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living an ...

, cell growth in vitro and enzymatic markers.R. Mertelsmann, M. A. Moore, B. Clarkson: ''Leukemia cell phenotype and prognosis: an analysis of 519 adults with acute leukemia.'' In: ''Blood Cells.'' 1982;8(3), S. 561–583. R. Mertelsmann, H. Tzvi Thaler, L. To, T. S. Gee, S. McKenzie, P. Schauer, A. Friedman, Z. Arlin, C. Cirrincione, B. Clarkson: ''Morphological classification, response to therapy, and survival in 263 adult patients with acute nonlymphoblastic leukemia.'' In: ''Blood.'' 1980 Nov;56(5), S. 773–781. . By using all techniques available at the time for phenotypic characterization of leukemia cells, he was successful in discovering and describing novel subentities of acute leukemias.N. Ciobanu, M. Andreeff, B. Safai, B. Koziner, R. Mertelsmann: ''Lymphoblastic neoplasia in a homosexual patient with Kaposi’s sarcoma.'' In: ''Ann Intern Med.'' 1983 Feb;98(2), S. 151–155. .R. Mertelsmann, B. Koziner, R. Ralph, D. Filippa, S. McKenzie, Z. A. Arlin, T. S. Gee, M. A. Moore, B. D. Clarkson: ''Evidence for distinct lymphocytic and monocytic populations in a patient with terminal transferase—positive acute leukemia.'' In: ''Blood.'' 1978 Jun;51(6), S. 1051–1056.

New therapeutic Modalities

In Cooperation with Karl Welte and his colleagues at

MSKCC Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a oncology, cancer treatment and research institution in Manhattan in New York City. MSKCC is one of 72 National Cancer Institute–NCI-designated Cancer Center, designated Comprehen ...

the purification and molecular and biological characterization of cytokines, important regulators of cell division, differentiation and migration, were the focus of his work in the following years at MSKCC.

Interleukin-2 Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It is a 15.5–16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) ...

K. Welte, C. Y. Wang, R. Mertelsmann, S. Venuta, S. P. Feldman, M. A. Moore: ''Purification of human interleukin 2 to apparent homogeneity and its molecular heterogeneity.'' In: ''J Exp Med.'' 1982 Aug 1;156(2), S. 454–464. as well as

K. Welte, E. Platzer, L. Lu, J. L. Gabrilove, E. Levi, R. Mertelsmann, M. A. Moore: ''Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor.'' In: ''Proc Natl Acad Sci U S A.'' 1985 Mar;82(5), S. 1526–1530. were purified to homogeneity, First translational and clinical studies of cytokines followed.R. Mertelsmann, K. Welte, C. Sternberg, R. O'Reilly, M. A. Moore, B. D. Clarkson, H. F. Oettgen: ''Treatment of immunodeficiency with interleukin-2: initial exploration.'' In: ''J Biol Response Mod.'' 1984 Oct;3(5), S. 483–490. Since experiments in murine models demonstrated that local production by gene transduced cells produced a stronger and more specific immune response than a systemic application, e.g. of Interleukin-2, this strategy was also pursued by his group in Phase I clinical trials.H. Glimm, K. Flügge, D. Möbest, V. M. Hofmann, J. Postmus, R. Henschler, W. Lange, J. Finke, H. P. Kiem, G. Schulz, F. Rosenthal, R. Mertelsmann, C. von Kalle: ''Efficient serum-free retroviral gene transfer into primitive human hematopoietic progenitor cells by a defined, high-titer, nonconcentrated vector-containing medium.'' In: ''Hum Gene Ther.'' 1998 Apr 10;9(6), S. 771–778. .H. Veelken, A. Mackensen, M. Lahn, G. Köhler, D. Becker, B. Franke, U. Brennscheidt, P. Kulmburg, F. M. Rosenthal, H. Keller, J. Hasse, W. Schultze-Seemann, E. H. Farthmann, R. Mertelsmann, A. Lindemann: ''A phase-I clinical study of autologous tumor cells plus interleukin-2-gene-transfected allogeneic fibroblasts as a vaccine in patients with cancer.'' In: ''Int J Cancer.'' 1997 Jan 27;70(3), S. 269–277. G. Stingl, E. B. Brŏcker, R. Mertelsmann, K. Wolff, S. Schreiber, E. Kămpgen, A. Schneeberger, W. Dummer, U. Brennscheid, H. Veelken, M. L. Birnstiel, K. Zatloukal, W. Schmidt, G. Maass, E. Wagner, M. Baschle, M. Giese, E. R. Kempe, H. A. Weber, T. Voigt: ''Phase I study to the immunotherapy of metastatic malignant melanoma by a cancer vaccine consisting of autologous cancer cells transfected with the human IL-2 gene.'' In: ''Hum Gene Ther.'' 1996 Mar 1;7(4), S. 551–563. These studies contributed to the later, successful clinical implementation of gene therapy for this and other indications.

Clinical Studies

In clinical trials for patients with leukemias and lymphomas at the MSKCCR. Mertelsmann, R. L. Drapkin, T. S. Gee, S. Kempin, S. Passe, H. T. Thaler, Z. Arlin, M. Dowling, P. Dufour, S. McKenzie, L. To, E. Comacho, H. F. Oettgen, J. H. Burchenal, B. Clarkson: ''Treatment of acute nonlymphocytic leukemia in adults: response to 2,2-anhydro-1-B-D-arabinofuranosyl-5-fluorocytosine and thioguanine on the L-12 protocol.'' In: ''Cancer.'' 1981 Nov 15;48(10), S. 2136–2142. and subsequently in German and European clinical trial groups,M. Pfreundschuh, J. Schubert, M. Ziepert, R. Schmits, M. Mohren, E. Lengfelder, M. Reiser, C. Nickenig, M. Clemens, N. Peter, C. Bokemeyer, H. Eimermacher, A. Ho, M. Hoffmann, R. Mertelsmann, L. Trümper, L. Balleisen, R. Liersch, B. Metzner, F. Hartmann, B. Glass, V. Poeschel, N. Schmitz, C. Ruebe, A. C. Feller, M. Loeffler: ''German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL). Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60).'' In: ''Lancet Oncol.'' 2008 Feb;9(2), S. 105–116. . Epub 2008 Jan 15. O. Determann, E. Hoster, G. Ott, H. Wolfram Bernd, C. Loddenkemper, M. Leo Hansmann, T. E. Barth, M. Unterhalt, W. Hiddemann, M. Dreyling, W. Klapper: ''European Mantle Cell Lymphoma Network and the German Low Grade Lymphoma Study Group. Ki-67 predicts outcome in advanced-stage mantle cell lymphoma patients treated with anti-CD20 immunochemotherapy: results from randomized trials of the European MCL Network and the German Low Grade Lymphoma Study Group.'' In: ''Blood.'' 2008 Feb 15;111(4), S. 2385–2387. Epub 2007 Dec 12. new therapeutic concepts were studied including classical chemotherapies as well as novel therapeutic strategies.H. P. Koeffler, D. Heitjan, R. Mertelsmann, J. E. Kolitz, P. Schulman, L. Itri, P. Gunter, E. Besa: ''Randomized study of 13-cis retinoic acid v placebo in the myelodysplastic disorders.'' In: ''Blood.'' 1988 Mar;71(3), S. 703–708. . 309: W. Hiddemann, H. Kreutzmann, K. Straif, W. D. Ludwig, R. Mertelsmann, M. Planker, R. Donhuijsen-Ant, E. Lengfelder, Z. Arlin, T. Büchner: ''High-dose cytosine arabinoside in combination with mitoxantrone for the treatment of refractory acute myeloid and lymphoblastic leukemia.'' In: ''Semin Oncol.'' 1987 Jun;14(2 Suppe 1), S. 73–77. E. J. Gold, R. H. Mertelsmann, L. M. Itri, T. Gee, Z. Arlin, S. Kempin, B. Clarkson, M. A. Moore: ''Phase I clinical trial of 13-cis-retinoic acid in myelodysplastic syndromes.'' In: ''Cancer Treat Rep.'' 1983 Nov;67(11), S. 981–986. For some rare, generally lethal cancers, the innovative use of rapidly recycling classical chemotherapy combinations followed by immediate High Dose Chemotherapy with HSC transplantation, led to long term remission and probably cures, which had not been seen with other therapies and in historical controls.L. Houet, I. Möller, M. Engelhardt, G. Köhler, H. Schmidt, D. Herchenbach, M. Schnitzler, A. Schmitt-Graeff, A. A. Jungbluth, R. Mertelsmann, B. Rumstadt, C. F. Waller: ''Long-term remission after CD34+-selected PBSCT in a patient with advanced intra-abdominal desmoplastic small round-cell tumor.'' In: ''Bone Marrow Transplant.'' 2010 Apr;45(4), S. 793–795. doi:10.1038/bmt.2009.226. Epub 2009 Aug 31. As clinical oncologist Mertelsmann also search for novel strategies to not only prolong life, but to increase quality of life. The systematic development of aerobic training programs for cancer patients undergoing chemotherapy and bone morrow transplantationF. Dimeo, H. Bertz, J. Finke, S. Fetscher, R. Mertelsmann, J. Keul: ''An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation.'' In: ''Bone Marrow Transplant.'' 1996 Dec;18(6), S. 1157–1160. . was highly successful and is now being used in many cancer centers worldwide.

Accusation of scientific misconduct

Mertelsmann was involved in a

scientific misconduct Scientific misconduct is the violation of the standard codes of scholarly method, scholarly conduct and ethics, ethical behavior in the publication of professional science, scientific research. It is the violation of scientific integrity: violati ...

affair in 1997. The complaint focussed on the falsification of laboratory data. An investigation commission did not prove the active participation of Mertelsmann.Klaus Koch
''Fälschungsskandal – Verjährt und zugenäht.''
auf: ''aerzteblatt.de''

Academic memberships

Mertelsmann is or was member of many international scientific organizations or journals, among them many years at the journals ''

European Journal of Cancer The ''European Journal of Cancer'' (abbreviated as ''EJC'' or ''Eur. J. Cancer'') is a peer-reviewed medical journal devoted to cancer research on experimental oncology, clinical oncology (medical, paediatric, radiation, surgical), and on cancer ep ...

'' and ''Annals of Hematology''. He is a foundation member of the ''Comprehensive Cancer Center Freiburg'' (CCCF), Initiator and director of the ''International Biomedical Exchange Program'' (IMEP), founder of the ''ARGER-Foundation'',ARGER Foundation
/ref> editor of the ''SRC-SDARF-UJDRF Joint Programme in Stem Cell Research'', Stockholm and president of the ''International Association for Comparative Research on Leukemia and related Diseases'' (IACRLD). Other select memberships: * 1979 American Society for Clinical Oncology * 1979 American Society for Hematology * 1979

American Association for Cancer Research The American Association for Cancer Research (AACR) is the world's oldest and largest professional association related to cancer research. Based in Philadelphia, the AACR focuses on all aspects of cancer research, including Basic research, basic, ...

* 1979

New York Academy of Sciences The New York Academy of Sciences (NYAS), originally founded as the Lyceum of Natural History in January 1817, is a nonprofit professional society based in New York City, with more than 20,000 members from 100 countries. It is the fourth-oldes ...

* 1990 European Society of Medical Oncology * 1993

Royal Society of Medicine The Royal Society of Medicine (RSM) is a medical society based at 1 Wimpole Street, London, UK. It is a registered charity, with admission through membership. Its Chief Executive is Michele Acton. History The Royal Society of Medicine (R ...

* 1997 International Society for Hematotherapy and Graft Engineering * 1998 American Society for Gene Therapy

Awards

* 1976 Konjetzny Prize for Cancer Research * 1980 Vincenz Czerny Award for Cancer Research (DGHO) * 1982 Boyer Award for Clinical Investigation (MSKCC) * 1985 Warner Award for Cancer Research (Warner Foundation) * 1990 Hamilton-Farley Award (ESMO) * 2000 Excellency Award, 13th International Symposium, Molecular Biology of Hematopoiesis, New York City * 2005 Professor honoris causa, Universidad del Salvador, Buenos Aires, Argentinien * 2007 Doctor honoris causa, university "Gr. T. Popa", Iasi, Rumänien * 2008 Professor honoris causa,

Universidad de Buenos Aires The University of Buenos Aires (, UBA) is a public research university in Buenos Aires, Argentina. It is the second-oldest university in the country, and the largest university of the country by enrollment. Established in 1821, the UBA has educa ...

(UBA), Buenos Aires, Argentinien * 2011 Doctor honoris causa, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

Publications

Articles in journals
Publication list ResearchGate

PubMed Publication list
Books (selection) * ''Das Blaue Buch: Chemotherapie-Manual Hämatologie und Internistische Onkologie.'' 5. Auflage. Springer Medizin, Berlin 2014, . * ''Das Rote Buch: Hämatologie und Internistische Onkologie.'' 5., überarb. und erw. Auflage. ecomed Medizin, Heidelberg 2014, . * mit Monika Engelhardt: ''Perspektiven einer zukünftigen Medizin und eines sich wandelnden Arztbildes.'' Rombach 2008, . * ''Leukämien und maligne Lymphome.'' Thieme, Stuttgart 1981. * mit Monika Engelhardt, Dietmar P. Berger und Philippe Moreau (eds.): ''Précis d'hématologie et d'oncologie.'' Springer, Paris 2011, .

References

External links

Roland Mertelsmann – Drang zur Weltspitze (Wissenschaft.de Archiv)

Aufklärung ohne Konsequenz (ZEIT Online 2001)

Persönliche Erklärung von Prof. Mertelsmann über wiss. Fälschungen
{{DEFAULTSORT:Mertelsmann, Roland German oncologists German hematologists 20th-century German physicians 21st-century German physicians 1944 births Living people